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Development of Aloe Vera and Calendula Extract Loaded Hydrogel Microneedle for Wound Dressing

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Abstract:

This study developed collagen-PVA hydrogel microneedles containing Aloe vera and Calendula officinalis for wound dressing. Microneedles with different Aloe vera: Calendula officinalis ratios 1:3, 1:1, and 3:1 were evaluated for swelling, mechanical strength, and antibacterial activity. Higher Aloe vera enhanced swelling, flexibility, and Escherichia coli inhibition, while higher Calendula officinalis improved tensile strength and Staphylococcus aureus inhibition. The 1:1 ratio offered the most balanced performance, demonstrating potential for effective wound healing applications.

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Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 72 View Preview

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Periodical:

Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 72)

Pages:

31-37

DOI:

https://doi.org/10.4028/p-o73vXB

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Online since:

May 2026

Authors:

Sittipark Thamronganansakul, Patipankawee Keawkongnok, Duangkanok Tanangteerapong*

Keywords:

Aloe Vera Extract, Calendula Officinalis Extract, Hydrogel Microneedles, Wound Dressing

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© 2026 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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