Al₂O₃ Nanopowders, a Suitable Compound for Active Control of Biofouling

Abstract:

The formation of biofilm (Biofouling) in different surface is the great concern in types of fields, especially in medical and health system as well as in membrane technology. The present study deals with the synthesis and characterization of Al₂O₃ nanopowders with antibacterial activity which can be a potentially utilized material for biocompatible implants. Nanostructure was synthesized based on sol-gel method and then, crystallite size, and microstructural and morphological characterization of nanostructure were determined by X-ray diffraction, electron-microscopic techniques - scanning electron microscopy (SEM) and transmission electron microscopy (TEM). According to X-ray diffraction, the value of particle size for Al2O3 nanopowders is 20.85 nm. In the following, the antibacterial activity of Al₂O₃ nanoparticles was assessed on three gram positive and three gram negative bacteria by radial diffusion assay and measurement of minimum inhibitory concentration (MIC). The toxicity of Al₂O₃ nanopowders on blood cells was also assessed. The results showed that this nanostructure has potent antibacterial activity against gram positive and gram negative bacteria. The synthesized Al₂O₃ nanopowders showed the antimicrobial activity against antibiotic resistant bacterium, Staphylococcus aureus. Significant antibacterial activity of this nanostructure was seen to have a greatest effect on Bacillus cereus with the MIC value of 9.2 μg/ml; while, among bacterial strains, Salmonella typhimurium was investigated to be the most resistant one with the MIC of 35.6 μg/ml. Al₂O₃ nanopowders showed no toxicity on blood cells. according to acquired data in this study, Al₂O₃ nanopowders may be a good material for inhibition of biofilm formation.

• Periodical: Journal of Nano Research (Volume 32)
• Pages: 71-80
• DOI: https://doi.org/10.4028/www.scientific.net/JNanoR.32.71
• Online since: May 2015
• Authors: Mohsen Mehregan, Hossein Soltaninejad, Behnaz Toluei Nia, Hadi Zare-Zardini*, Masoud Zare-Shehneh, Leila Ebrahimi
• Keywords: Al₂O₃ Nanopowders, Antibacterial, Biofouling, Blood Cells, Minimum Inhibitory Concentration, Toxicity

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