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The Influence of Geometrically Configured Sol-Gel Derived Hydroxyapatite Substrates on Osteoblast Response

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Abstract:

Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ~350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400 °C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast’s response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the longterm performance of prosthetic orthopedic and dental implants.

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Periodical:

Key Engineering Materials (Volumes 284-286)

Pages:

569-572

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.569

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Online since:

April 2005

Authors:

Daniel Adams, Regina D. Smith, Gerald F. Malgas, S.P. Massia, T.L. Alford, J.W. Mayer

Keywords:

Hydroxyapatite (HAP), Microwave Annealing (MWA), Osteoblast, Topographical Features

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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