The Influence of Geometrically Configured Sol-Gel Derived Hydroxyapatite Substrates on Osteoblast Response
Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ~350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400 °C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast’s response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the longterm performance of prosthetic orthopedic and dental implants.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
D. Adams et al., "The Influence of Geometrically Configured Sol-Gel Derived Hydroxyapatite Substrates on Osteoblast Response ", Key Engineering Materials, Vols. 284-286, pp. 569-572, 2005