Bioactivity of the Two Kinds of Biodegradable Composite Membrane Containing Oriented Needle-Like Apatite

Abstract:

It is well known that bone morphogenetic protein (BMP) induces bone formation and requires for carriers. Poly-lactic acid / poly-glycolic acid (PLGA) is frequently used as the carriers of BMP. We developed a biodegradable composite PLGA membrane, which was containing oriented needle-like apatite with BMP. The composite membranes were implanted into the thigh muscle pouch of 3-week-old-mice. At 3 weeks after implantation, the implanted area was observed by optical microscopy. The composite membrane containing oriented needle-like apatite with BMP induced new bone formation. It seems that this composite membrane might be a scaffold of BMP and promoting the healing of bone defects.

• Periodical: Key Engineering Materials (Volumes 284-286)
• Pages: 811-814
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.284-286.811
• Online since: April 2005
• Authors: Toshiki Itoh, Seiji Ban, T. Watanabe, Shozo Tsuruta, Takahiro Kawai, Hiroshi Nakamura
• Keywords: Apatite, BMP, Composite, Membrane, PLGA

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