Bioactivity of the Two Kinds of Biodegradable Composite Membrane Containing Oriented Needle-Like Apatite

Abstract:

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It is well known that bone morphogenetic protein (BMP) induces bone formation and requires for carriers. Poly-lactic acid / poly-glycolic acid (PLGA) is frequently used as the carriers of BMP. We developed a biodegradable composite PLGA membrane, which was containing oriented needle-like apatite with BMP. The composite membranes were implanted into the thigh muscle pouch of 3-week-old-mice. At 3 weeks after implantation, the implanted area was observed by optical microscopy. The composite membrane containing oriented needle-like apatite with BMP induced new bone formation. It seems that this composite membrane might be a scaffold of BMP and promoting the healing of bone defects.

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Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

811-814

DOI:

10.4028/www.scientific.net/KEM.284-286.811

Citation:

T. Itoh et al., "Bioactivity of the Two Kinds of Biodegradable Composite Membrane Containing Oriented Needle-Like Apatite ", Key Engineering Materials, Vols. 284-286, pp. 811-814, 2005

Online since:

April 2005

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$35.00

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