Bioactivity of the Two Kinds of Biodegradable Composite Membrane Containing Oriented Needle-Like Apatite
It is well known that bone morphogenetic protein (BMP) induces bone formation and requires for carriers. Poly-lactic acid / poly-glycolic acid (PLGA) is frequently used as the carriers of BMP. We developed a biodegradable composite PLGA membrane, which was containing oriented needle-like apatite with BMP. The composite membranes were implanted into the thigh muscle pouch of 3-week-old-mice. At 3 weeks after implantation, the implanted area was observed by optical microscopy. The composite membrane containing oriented needle-like apatite with BMP induced new bone formation. It seems that this composite membrane might be a scaffold of BMP and promoting the healing of bone defects.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
T. Itoh et al., "Bioactivity of the Two Kinds of Biodegradable Composite Membrane Containing Oriented Needle-Like Apatite ", Key Engineering Materials, Vols. 284-286, pp. 811-814, 2005