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Paper Titles
Silicon Dissolution from Microporous Silicon Substituted Hydroxyapatite and its Effect on Osteoblast Behaviour
p.117
The Effect Orthosilicic Acid on Collagen Type I, Alkaline Phosphatase and Osteocalcin mRNA Expression in Human Bone-Derived Osteoblasts In Vitro
p.121
Preparation of Carbonate Apatite Monolith by Treatment of the Set Gypsum Containing Calcite in Trisodium Phosphate Solution
p.125
Preparation of Hollow and Spherical β-Calcium Orthophosphate Agglomerates: Effect of Organic Compound Addition to the Spraying Solution
p.129
Carbonate Substituted Hydroxyapatite; Development and Function of Osteoclasts
p.133
Fluoridated Ca-Deficient Apatite Formed Via Octacalcium Phosphate Enhances Bone Regeneration
p.137
F-Substituted Carbonate Apatite for Promoting Bone Formation
p.141
Polarization Energy Effect of Electrovector Hydroxyapatite on Bonelike Crystal Growth in SBF
p.145
Immediate Mechanism of the Osteoconductivity of the Polarized Hydroxyapatite
p.149

Carbonate Substituted Hydroxyapatite; Development and Function of Osteoclasts

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Abstract:

Human osteoclasts derived from CD14+ precursors were cultured on discs of stoichiometric hydroxyapatite (HA) and carbonate substituted hydroxyapatite (CHA) of varying carbonate contents. Resorption of the ceramic increased with increasing carbonate content up to 2.35 wt. %. Development of osteoclasts is qualitatively different on ceramics compared to dentine, occurring in discrete, confluent subpopulations, which suggests local cell signalling may be important in the process. Resorption appears to drive further development of osteoclasts. Controlling carbonate content may be one way of controlling the rate of resorption of synthetic HA ceramics.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

133-136

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.133

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Online since:

May 2006

Authors:

Gavin M. Spence, Nelesh Patel, Roger A. Brooks, D.C. Ireland, William Bonfield, Neil Rushton

Keywords:

Carbonate Substituted Hydroxyapatite, Hydroxyapatite (HAP), Osteoclast

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© 2006 Trans Tech Publications Ltd. All Rights Reserved

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