F-Substituted Carbonate Apatite for Promoting Bone Formation

Abstract:

Abstract. Fluoride (F-)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F- contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid – sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 µg L-1, which was 1.5~8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

• Periodical: Key Engineering Materials (Volumes 309-311)
• Pages: 141-144
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.309-311.141
• Online since: May 2006
• Authors: Yu Sogo, Daiki Yokoyama, Atsuo Ito, Atsushi Yamazaki, Racquel Z. LeGeros
• Keywords: Bone Substitute, Carbonate-Containing Hydroxyapatite, Fluoride, Release Property

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