Human Osteoclasts Behaviour on Sol-Gel Derived Carbonate Hydroxyapatite Coatings on Anodized Titanium Alloy Substrates

Abstract:

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Titanium alloy has been used as a material for orthopaedic implants, however drawbacks still exist. Considerable efforts have been taken to modify the surface structure of the implant material and improve the biological performance. Previously we have demonstrated that biomaterials surface modification has a significant effect on the regulation of osteogenesis. We have investigated the behaviour of human osteoclasts on sol-gel coated carbonated hydroxyapatite on anodized titanium alloy. Osteoclasts cultured on the modified surface were able to attach and spread, exhibiting the characteristic peripheral brush border. Successful differentiation of the monocytes into osteoclasts and their attachment to the coated surface and the formation of resorption-like imprints indicated that carbonate hydroxyapatite (CHAP) coated titanium alloy play a significant role in regulating the functional activity of osteoclasts.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

709-712

DOI:

10.4028/www.scientific.net/KEM.309-311.709

Citation:

Y. Ramaswamy et al., "Human Osteoclasts Behaviour on Sol-Gel Derived Carbonate Hydroxyapatite Coatings on Anodized Titanium Alloy Substrates ", Key Engineering Materials, Vols. 309-311, pp. 709-712, 2006

Online since:

May 2006

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Price:

$35.00

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