Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute

Q. Yao; Dong Xiao Li; K.W. Liu; Bo Zhang; H. Li; Hong Song Fan; Xing Dong Zhang

doi:10.4028/www.scientific.net/KEM.309-311.857

Paper Titles

Effect of Protein Addition on the Setting Behaviour of a Calcium Phosphate Cement
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Development and Characterization of β- Tricalcium Phosphate Cements Containing Chitosan
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Adhesion of a Novel Calcium Phosphate Cement to Cortical Bone and Several Common Biomaterials
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Investigation into Carboxylic Acids as Cement Reactants
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Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute
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Biodegradable Bone Cement Using Calcium Phosphate Glass
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Preparation and In Vitro Releasing of Salmon Calcitonin Carried Porous Injectable Calcium Phosphate Bone Cement
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Investigation on Self-Emerged Porous CPC Containing Chinese Medicine
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Comparative Investigation of Various Adding Methods on Synthesis of Calcium Phosphate Containing Chinese Medicine
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Primary Study of an Injectable In Situ Composite...

Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute

Abstract:

This study was to develop an injectable biocompatible and porous calcium phosphate collagen composite cement scaffold by in situ setting. TTCP was prepared as main material of the CPC powder, and the collagen solution was added into the phosphoric acid directly to form the liquid phase. The injectable time (tI), setting time (tS) and setting temperature (TS), along with the PH value were recorded during the setting process. The compressive strength, morphology and porosity were tested. With the increase of collagen, this novel CPC get a tI of 5mins to 8mins, tS of 20mins to 30mins, compressive strength from 1.5MPa to 4MPa, and the porosity from 40% to 60%. This study gave a possibility to form a porous scaffold of collagen/CPC composite with the nature of injectability and setting in situ.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

857-860

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.857

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Online since:

May 2006

Authors:

Q. Yao, Dong Xiao Li, K.W. Liu, Bo Zhang, H. Li, Hong Song Fan, Xing Dong Zhang

Keywords:

Bone Cement, Bone Substitute, Calcium Phosphate, Collagen Composite

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