Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix
Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
K. Tsuru et al., "Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix", Key Engineering Materials, Vols. 330-332, pp. 1177-1180, 2007