Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix

Abstract:

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Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

Info:

Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

1177-1180

DOI:

10.4028/www.scientific.net/KEM.330-332.1177

Citation:

K. Tsuru et al., "Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix", Key Engineering Materials, Vols. 330-332, pp. 1177-1180, 2007

Online since:

February 2007

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Price:

$35.00

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