Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix

Kanji Tsuru; Satoshi Hayakawa; Yuki Shirosaki; T. Okayama; K. Kataoka; N.H. Huh; Akiyoshi Osaka

doi:10.4028/www.scientific.net/KEM.330-332.1177

Paper Titles

Cell Repopulation in Calcium Phosphate Hybridized Tendon Graft
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Reconstructing Box-Like Bone Defect of Mandible with In Vivo Tissue Engineering Bone
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Mechanical Properties of Living Adherent Cells: Interaction of Cell and Shear Flow
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Comparison on the Osteogenesis Potential between Poly(lactide-Co-Glycolide) and Alginate as Bone Tissue Engineering Scaffold In Vivo
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Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix
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Effects of Mechanical Strain on Osteoblastic Precursor Cells in a Three-Dimensional Scaffold
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Repair of Articular Cartilage Defect with Cell-Loaded Nano-HA/PLGA Composites
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Effect of Surface Electrostatic Property on Chondrogenic Differentiation of Human Mesenchymal Stem Cells
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 330-332Preparation of Porous Organically-Modified...

Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix

Abstract:

Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

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Key Engineering Materials (Volumes 330-332)

Pages:

1177-1180

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.1177

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Online since:

February 2007

Authors:

Kanji Tsuru, Satoshi Hayakawa, Yuki Shirosaki, T. Okayama, K. Kataoka, N.H. Huh, Akiyoshi Osaka

Keywords:

Bioreactor, Cell Culture, HepG2, Inorganic-Organic Hybrids, Scaffold

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