The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc

Abstract:

In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

• Periodical: Key Engineering Materials (Volumes 342-343)
• Pages: 389-392
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.342-343.389
• Online since: July 2007
• Authors: Soon Hee Kim, Bang Sil Choi, Youn Kyung Ko, Hyun Jung Ha, Sun Jung Yoon, John M. Rhee, Moon Suk Kim, Hai Bang Lee, Gil Son Khang
• Keywords: FT-IR, MTT Assay, PLGA, Pore Size, Small Intestinal Submucosa

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