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Paper Title Page
Abstract: Dynamic stabilization of the lumbar spine has gained increasingly popularity. These
nonfusion systems are alleged to maintain or restore the intradiscal pressure to magnitudes of the
intact spine and have little negative effect on the adjacent segments to the stabilized one. Compliant
Nitinol alloy (Ni-Ti) has been used in the manufacture of the rods of the dynamic stabilization
systems. In this study, we investigated a dynamic stabilization system with its coiled rods made of
Nitinol alloy. Four porcine lumbar spines (T12-L6) were prepared: intact, fixed by a conventional
rigid fixation system, fixed by a dynamic stabilization system with 2-coiled rods, fixed by a
dynamic stabilization system with 3-coiled rods. Intradiscal pressures were measured at all levels
before and after insertion of the implant. Our results show that the rigid stabilization system resulted
in great changes of disc pressure in flexion and extension regardless of spinal levels. However,
Intradiscal pressures (IDPs) remained relatively unchanged in models fixed by the dynamic
stabilization systems. Changes in intradiscal pressure can lead to altered metabolism within the disc,
with potential long-term disc degeneration. These results suggest that the dynamic stabilization
systems are superior over traditional fusion implants in maintaining the intradiscal pressure to the
intact level at surgical level and adjacent level and can therefore be considered as an alternative
method to fusion surgery in these indications while the intradical pressure is preserved.
913
Abstract: To analyze the importance of bone quality, we studied 21 primary compressive trabecular
system by micro-computed tomography(micro-CT), finite element analysis and destructive
mechanical test. Significant correlations were found between histomorphometry and biomechanical
parameters. The results indicate that the bone quality of primary compressive trabecular system is
determined more by its combined micro-structural parameters (histomorphometry) and
biomechanical parameters than histomorphometry only. Assessment of trabecular bone by finite
element analysis may become important not only for assessment of bone quality but also for
prediction of bone fracture risk of bone degeneration.
917
Abstract: New medicines for treatment of osteoporotic bones have developed. In the previous
studies, there were lots of pre-clinical experiments on animals to analyze the virtue of new medicine.
However, the previous methods sacrificed a number of animals. They induced lots of expenses and
ethical problems. In the present study, to investigate the effect of a medicine for osteoporosis by
using in-vivo micro computed tomography (In-vivo Micro-CT, skyscan 1076, skyscan, Belgium)
and micro finite element (*FE) analysis, morphological and mechanical characteristic changes of
rat bone were detected and tracked. The 8 female Sprague-Dawley rats, used in the experiment,
were randomized into 3 groups (Control, Sham and Risedronate group). The Risedronate (actonel,
0.58mg/Kg and 5days/week) for 8 weeks was administered in RIS group. The 4th lumbar vertebrae
of rats were scanned by In-vivo Micro-CT with 35*m at week 0 (just before dose) and week 8 (after
dose). Three-dimensional (3D) structural parameters were calculated. Simulated compression tests
of 3D FE models were carried out to investigate the mechanical characteristics in the whole
vertebral bone model of the 4th lumbar vertebra. The change rate of quantity and structure in
Risedronate (RIS) group was smaller than that of control (CON) group. The change rate of
structural modulus in RIS group was also smaller than that of CON group. This result shows the
virtue of risedronate quantitatively as well as qualitatively. The study introduced the improved noninvasive
biomechanical evaluation method, combined with In-vivo Micro-CT and *FE analysis,
which was more effective and useful than the previous pre-clinical experiments.
921
Abstract: The emulsion stabilizing potential of chitosans was compared in the presence of organic
additives. The 4 types suspension of 0.1 wt% of chitosan flocculant were obtained by mixing of
chitosan colloidal dispersion with three kinds of additives; sorbic acid, benzoic acid and
dibutylhydroxytoluene (BHT). The viscosity of emulsion revealed the following order of stabilizing
potentials; sorbic acid > benzoic acid > BHT. As a bio-adsorbent for the treatment of biomedical
wastewater, the results were capable of adsorbing more than 30% of pure chitosan. The chitosan
emulsions represented that the removal efficiency were increased by COD 59.2%, BOD 70.1%, Zn
77.1%, Cu 93.7%, E. coli 99.4%. As a result of this investigation, it is remarked that the high
stabilizing potential of chitosan solution is explained by higher adsorption efficiency with organics,
heavy metals and microorganism, and that the effectiveness of chitosan solution for coagulating
biomedical wastewater suspension could be improved due to stabilization of the viscosity in the
presence of organic additives.
925
Abstract: As a natural biomaterial, collagen especially pepsin-solubilized collagen (type I) has been
used widely in biomedical fields due to its excellent biocompatibility. In this preliminary study, we
investigate the effect of some inorganic ions which are frequently utilized in the preparation of
collagen on the morphology and crystallinity of fibrils. The scanning electron microscope and x-ray
diffraction were applied to analyze the morphology and the crystallization of the reconstituted
collagen fibrils, respectively. Although further studies are needed, these initial results indicate that
by controlling the self-assembly conditions of collagen molecules, we may achieve the desired
properties of fibrillar collagen products.
929
Abstract: To use nanobiosensors as diagnostic devices, they should be evaluated and approved as
medical devices before marketing. This study was performed to establish appropriate evaluation
guidelines that provide how to verify the safety and effectiveness of a novel nanobiosensor as a
medical device. We prepared an enzymeless glucose sensor with nanoporous platinum electrode
to evaluate performance and stability by comparing it with a commercial enzyme-based glucose
sensor. Through these evaluation studies, we developed guidelines, and the guidelines consist of
five parts: evaluation of analytical performance, clinical performance, safety, stability, and design
and quality control systems. Analytical and clinical performance of nanobiosensors should be
evaluated by accuracy, sensitivity, reproducibility, cut-off value, and other specific performance
characteristics. Also, electric, mechanical, and biological safety should be evaluated. With the
performance and safety, validation of storing conditions and shelf life should be established with
evaluation and characterization of nano-structured parts for stability evaluation. Then, design and
quality control systems should be evaluated in the aspect of quality requirements, material,
manufacturing process, and final product. These guidelines will be helpful for facilitating the
commercialization of the safe, effective, and novel diagnostic nanobiosensors into market place.
933
Abstract: The purpose of this study was to investigate the remineralization effect of Galla Rhois
and Psoralea corylifolia extracts with sodium fluoride (NaF), and interaction between the herbal
extracts and NaF in dentifrice using the microbiological pH cycling model on artificial caries
enamel. For the analysis, Surface hardness score of the enamel lesion on bovine teeth was measured,
before and after the microbiological pH cycling sequences for 15 days. It showed that fluoride
group was more higher surface hardness score than non fluoride group, and there were no
significant differences among test dentifrices in each group. Thus, it is suggested that Galla Rhois
and Psoralea corylifolia extracts with NaF have the remineralization effect on tooth surface. And
there was no antagonistic interaction between those herbal extarcts and NaF in dentifrice.
937
Abstract: The main objective of this study was to manufacture an oral rinse using the natural
antibacterial agent (phytosphingosine, Doosan, Korea) for the prevention of periodontal disease and
dental caries. Phytosphingosine is known to inhibit the growth of bacterial strains and induce
apoptotic cell death in human cancer lines. In this study, antibacterial activity and cytotoxicity of
oral rinses were performed with an experimental group containing phytosphingosine(PS) in vitro.
Control groups consist of two Korean products and two American products containing
chlorhexidine and cetylpyridinium chloride, respectively. There was no significant difference
between experimental and control groups in the antibacterial activity and cytotoxicity except for
Chika Chika Liq (p<0.05). According to the results, antibacterial activity of oral rinse containing PS
was 99.62%, the strongest contact inhibition of Streptococcus mutans strain among tested groups. In
the cytotoxicity test of oral rinses, PS had a weaker cytotoxicity than control groups in mouse and
human normal cell lines and showed the strongest cytotoxicity in human oral cancer cell lines (KB
cell). From the results, PS may be widely used as an oral rinse for the healthy and the patients with
oral cancers in the near future.
941
Abstract: We developed the successive roller type of microneedle system without pain to improve
the permeation of drug through the skin barrier. The permeation rates of FITC-ovalbumin (OVA,
MW: 45,000g/mole), FITC-insulin (MW: 5,733 g/mole) and FITC-bufexamac (MW: 227.37
g/mole) as model drugs were determined by modified Franz diffusion cells using the microneedle
device with four times treatment. The average penetration fluxes of FITC- OVA, FITC-insulin and
FITC-bufexamac were steeply increased from 13.4 to 83.3, 10.1 to 110.6 and 11.9 to 242.6
pmol/cm2 with treatment for 12 hrs, respectively. The lower the molecular weight of the drugs, the
more the permeation flux investigated. In conclusion, we confirmed the possibility of the
application for transdermal delivery of the larger molecular drugs as protein using the designed
microneedle treatment device.
945