Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats

C.S. Lim; S.G. Kim; Sung Chul Lim

doi:10.4028/www.scientific.net/KEM.361-363.1261

Paper Titles

Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP® Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit
p.1245

Quantitative Micro-Radiography of New Bones Formed around the Implant Using Parametrics X-Ray
p.1249

Bone Regenerative Property of Octacalcium Phosphate in Mouse Critical Sized Calvarial Defects
p.1253

Comparison of New Bone Formation and Osteotomy Speed in the Rabbit Mandible Using Piezoelectric Surgery and Conventional Burs
p.1257

Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats
p.1261

Hybrid Chitosan Membranes Tested in Sheep for Guided Tissue Regeneration
p.1265

Stimulatory Effect on Osseous Repair of Zinc-Substituted Hydroxyapatite: Histological Study in Rabbit’s Tibia
p.1269

Effect of Hydroxyapatite and Zinc-Containing Hydroxyapatite on Osseous Repair of Critical Size Defect in the Rat Calvaria
p.1273

Improvement of Radio Opacity of Injectable Bone Substitute MBCP Gel^TM for Minimal Invasive Surgery MIS
p.1277

HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363Effect of Synthetic β-TCP and Bovine-Derived...

Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats

Abstract:

We evaluated the bone healing effect of grafting with synthetic β-tricalcium phosphate (β-TCP; Cerasorb®), bovine-derived hydroxyapatite (HA; Bio-Oss®), and a mixture of β-TCP and HA in rats. Each material was grafted in prepared 8-mm frontal bone defects in 15 rats. The control group underwent surgery without any grafting materials and was examined after 4 weeks, whereas the experimental groups received grafting materials and were examined after 1, 2, and 4 weeks. After implantation, the rats were sacrificed for histomorphometric studies using light microscopy, and the data were analyzed using analysis of variance. Considerable inflammation and fibrosis were observed after 1 and 2 weeks in all experimental groups, whereas the inflammation was reduced and fibrosis was stabilized after 4 weeks. New bone formation was observed at the defect margin. Statistically, there was no difference in new bone formation among the three experimental groups. In conclusion, there was no difference in new bone formation using Bio-Oss®, Cerasorb®, and a mixture of Bio-Oss® and Cerasorb®.