Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats

Abstract:

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We evaluated the bone healing effect of grafting with synthetic β-tricalcium phosphate (β-TCP; Cerasorb®), bovine-derived hydroxyapatite (HA; Bio-Oss®), and a mixture of β-TCP and HA in rats. Each material was grafted in prepared 8-mm frontal bone defects in 15 rats. The control group underwent surgery without any grafting materials and was examined after 4 weeks, whereas the experimental groups received grafting materials and were examined after 1, 2, and 4 weeks. After implantation, the rats were sacrificed for histomorphometric studies using light microscopy, and the data were analyzed using analysis of variance. Considerable inflammation and fibrosis were observed after 1 and 2 weeks in all experimental groups, whereas the inflammation was reduced and fibrosis was stabilized after 4 weeks. New bone formation was observed at the defect margin. Statistically, there was no difference in new bone formation among the three experimental groups. In conclusion, there was no difference in new bone formation using Bio-Oss®, Cerasorb®, and a mixture of Bio-Oss® and Cerasorb®.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

1261-1264

DOI:

10.4028/www.scientific.net/KEM.361-363.1261

Citation:

C.S. Lim et al., "Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats", Key Engineering Materials, Vols. 361-363, pp. 1261-1264, 2008

Online since:

November 2007

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$35.00

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