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Hybrid Chitosan Membranes Tested in Sheep for Guided Tissue Regeneration

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Abstract:

Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1265-1268

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1265

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Cite this paper

Online since:

November 2007

Authors:

P.P. Cortez, Yuki Shirosaki, C.M. Botelho, M.J. Simões, F. Gartner, R.M. Gil da Costa, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, M.A. Lopes, José D. Santos, Ana Colette Maurício

Keywords:

Biodegradable Membrane, Chitosan (CS), Chitosan Silicate Hybrid, Guided Tissue Regeneration, In Vivo Study

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© 2008 Trans Tech Publications Ltd. All Rights Reserved

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