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A Novel Bone Scaffolds Based on Hyperbranched Polyglycerol Fibers Filled with Hydroxyapatite Nanoparticles: In Vitro Cell Response

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Abstract:

A novel bone scaffolding material was successfully fabricated by electrospinning from hyperbranched polyglycerol (HPGL) solutions containing nanoparticles of hydroxyapatite (HA). The potential use of the electrospun fibrous HPGL-HA scaffolds for bone regeneration was evaluated in vitro with human osteoblasts in terms of alkaline phosphatase (ALP) activity of the cells that were cultured directly on the scaffolds. The results were compared with those on corresponding HPLG-HA solution-cast film scaffolds. It was found that all of the fibrous scaffolds promoted much better adhesion and proliferation of cells than the corresponding film scaffolds.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

633-636

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.633

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Online since:

October 2008

Authors:

Alvaro Antonio Alencar de Queiroz, José Carlos Bressiani, Ana Helena A. Bressiani, Olga Z. Higa, Gustavo Abel Abraham

Keywords:

Electrospun, Hydrogel, Hydroxyapatite (HAP), Hyperbranched Polyglycerol, Scaffold, Tissue Engineering

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© 2009 Trans Tech Publications Ltd. All Rights Reserved

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