Comparison of Hydroxyapatite and AB-Type Carbonate-Substituted Hydroxyapatite Suspensions for Use in the Reticulated Foam Method of Scaffold Production
Precipitation routes for HA production result in the formation of suspensions of nano-scale hydroxyapatite particles in water. During this work, suspensions of phase-pure and carbonate-substituted hydroxyapatite were produced using a precipitation reaction with calcium hydroxide and orthophosphoric acid as reactants. The chemistry of the apatites was analysed using XRD and FTIR after heat treatment in various atmospheres and the particle morphology investigated using TEM. The thermal stability of the carbonate HA was found to be significantly less than the phase-pure HA and dependent upon the heat-treatment atmosphere. Suspensions were used directly for replication of polymer foam templates with a dip-coating technique. Good replication of the foam structure was achieved with the phase pure hydroxyapatite, but no structural integrity was achieved with the carbonate-HA structure possibly a result of limits on the sintering temperature.
Marcelo Prado and Cecília Zavaglia
J.H. Robinson and S. Best, "Comparison of Hydroxyapatite and AB-Type Carbonate-Substituted Hydroxyapatite Suspensions for Use in the Reticulated Foam Method of Scaffold Production", Key Engineering Materials, Vols. 396-398, pp. 649-652, 2009