Evaluation and Biocompatibility of a New Type of Scaffold for Tissue Growth Based on Calcium Phosphate Cement

Jéferson Luis de Moraes Machado; Luis Alberto Santos

doi:10.4028/www.scientific.net/KEM.396-398.667

Paper Titles

Comparison of Hydroxyapatite and AB-Type Carbonate-Substituted Hydroxyapatite Suspensions for Use in the Reticulated Foam Method of Scaffold Production
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Development of Calcium Phosphate Mineralized Silk for Potential Use in Guided Bone Regeneration: Preparation and Properties
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Effect of Hydroxyapatite on Biodegradable Scaffolds Fabricated by SLS
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Effect of Saturation and Post Processing on 3D Printed Calcium Phosphate Scaffolds
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Evaluation and Biocompatibility of a New Type of Scaffold for Tissue Growth Based on Calcium Phosphate Cement
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In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction
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Macroporous Calcium Phosphate Bioceramics as Drug Release Agents: A Kinetics Study of Ampicillin Release
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Manufacturing of Porous Alumina Scaffolds with Bio-Glass and HAp Coating: Mechanical and In Vitro Evaluation
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Modified Gelcasting Process to Prepare Porous Trifasic and Bifasic Hydroxyapatite Scaffolds
p.683

HomeKey Engineering MaterialsKey Engineering Materials Vols. 396-398Evaluation and Biocompatibility of a New Type of...

Evaluation and Biocompatibility of a New Type of Scaffold for Tissue Growth Based on Calcium Phosphate Cement

Abstract:

Growth of cells in three-dimensional porous scaffolds has gaining importance in the field of tissue engineering. The scaffolds guide cellular growth, synthesize extra-cellular matrix and other biological molecules, and make the formation of tissues and functional organs easier. The aim of this work was to use α-TCP (α-tricalcium phosphate) cement in order to obtain such scaffolds, with the aid of paraffin spheres as pores generators. These spheres were produced by suspension in an aqueous solution of polyvinylalcohol (PVA) and sodium sulphate (Na2SO4). The porosity of the scaffolds produced with paraffin spheres was analyzed and compared to the literature, and the study of scaffolds permeability using Forchenheimer equation allowed the analysis of pores interconnectivity. In vitro tests showed the behavior of scaffolds in solutions of SBF (Simulated Body Fluid), and viability and cell proliferation were also evaluated. Use of paraffin spheres showed to be appropriate to the formation of pores suitable size to allow cellular growth.

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Periodical:

Key Engineering Materials (Volumes 396-398)

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667-670

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.667

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Online since:

October 2008

Authors:

Jéferson Luis de Moraes Machado, Luis Alberto Santos

Keywords:

Forchenheimer Equation, Scaffold, Tricalcium Phosphate Cement

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