In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction
Bioactive glass/polymer hybrids are promising materials for biomedical applications because they combine the bioactivity of these bioceramics with the flexibility of polymers. In previous work hybrid foams with 50% bioactive glass and 50% polyvinyl alcohol (PVA) were prepared by the sol-gel process for application as scaffold for bone tissue engineering. In this work the hybrid samples were tested in osteoblast culture to evaluate adhesion and proliferation. Samples were also implanted subcutaneously in the dorsal region of adult rats. The hybrid 50% PVA/bioactive glass foam was chosen as the best scaffold in the composition range studied and it is a promising material for bone repair, providing a good environment for the adhesion and proliferation of osteoblasts in vitro. Concerning the in vivo studies we can assure that the “foreing body” reaction was moderate and that the presence of osteoid indicated bone matrix formation.
Marcelo Prado and Cecília Zavaglia
V. Gomide et al., "In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction", Key Engineering Materials, Vols. 396-398, pp. 671-674, 2009