In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction

Viviane Gomide; Natália Ocarino; Rogéria Serakides; Maria de Fatima Leite; Marivalda Pereira

doi:10.4028/www.scientific.net/KEM.396-398.671

Paper Titles

Development of Calcium Phosphate Mineralized Silk for Potential Use in Guided Bone Regeneration: Preparation and Properties
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Effect of Hydroxyapatite on Biodegradable Scaffolds Fabricated by SLS
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Effect of Saturation and Post Processing on 3D Printed Calcium Phosphate Scaffolds
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Evaluation and Biocompatibility of a New Type of Scaffold for Tissue Growth Based on Calcium Phosphate Cement
p.667

In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction
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Macroporous Calcium Phosphate Bioceramics as Drug Release Agents: A Kinetics Study of Ampicillin Release
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Manufacturing of Porous Alumina Scaffolds with Bio-Glass and HAp Coating: Mechanical and In Vitro Evaluation
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Modified Gelcasting Process to Prepare Porous Trifasic and Bifasic Hydroxyapatite Scaffolds
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Morphological Characterization of 3D Porous Scaffolds Based on Portland Cement
p.687

HomeKey Engineering MaterialsKey Engineering Materials Vols. 396-398In Vitro and In Vivo Evaluation of Bioactive...

In Vitro and In Vivo Evaluation of Bioactive Glass/PVA Porous Hybrids for Application in Bone Reconstruction

Abstract:

Bioactive glass/polymer hybrids are promising materials for biomedical applications because they combine the bioactivity of these bioceramics with the flexibility of polymers. In previous work hybrid foams with 50% bioactive glass and 50% polyvinyl alcohol (PVA) were prepared by the sol-gel process for application as scaffold for bone tissue engineering. In this work the hybrid samples were tested in osteoblast culture to evaluate adhesion and proliferation. Samples were also implanted subcutaneously in the dorsal region of adult rats. The hybrid 50% PVA/bioactive glass foam was chosen as the best scaffold in the composition range studied and it is a promising material for bone repair, providing a good environment for the adhesion and proliferation of osteoblasts in vitro. Concerning the in vivo studies we can assure that the “foreing body” reaction was moderate and that the presence of osteoid indicated bone matrix formation.

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Key Engineering Materials (Volumes 396-398)

Pages:

671-674

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.671

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Online since:

October 2008

Authors:

Viviane Gomide, Natália Ocarino, Rogéria Serakides, Maria de Fatima Leite, Marivalda Pereira

Keywords:

Bioactive Glass, Osteoblast, Polymer Hybrids, Subcutaneous Implants

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