In Vivo Behaviour of the Synthetic Porous Hydroxyapatite Prepared by Low Temperature Microwave Processing and Comparison with Deproteinized Bovine Bone

M. Strnadová; Z. Strnad; Pavel Šponer; Jana Jirošova; J. Strnad

doi:10.4028/www.scientific.net/KEM.493-494.236

Paper Titles

Preparation of Submicron-Sized Hydroxyapatite Powders by Spray Pyrolysis
p.215

Recrystallization of Amorphized α-TCP
p.219

Raman and Infrared Studies of Substituted β-TCP
p.225

The Effect of Microwave Irradiation on Structural and Mechanical Properties of Nano-Structured Bone-Like Carbonated Hydroxyapatite
p.231

In Vivo Behaviour of the Synthetic Porous Hydroxyapatite Prepared by Low Temperature Microwave Processing and Comparison with Deproteinized Bovine Bone
p.236

Standardized Study of Carbonate Apatite as Bone Substitute in Rabbit’s Tibia
p.242

In Vivo and In Vitro Biocompatibility Study of Nanostructured Carbonate-Apatite
p.247

Osseoinduction Evaluation of Hydroxyapatite and Zinc Containing Hydroxyapatite Granules in Rabbits
p.252

Effect of Carbonate-Apatite on Bone Repair in Non-Critical Size Defect of Rat Calvaria
p.258

HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494In Vivo Behaviour of the Synthetic Porous...

In Vivo Behaviour of the Synthetic Porous Hydroxyapatite Prepared by Low Temperature Microwave Processing and Comparison with Deproteinized Bovine Bone

Abstract:

The aim of this study was to evaluate the osteoconductive properties of synthetic porous hydroxyapatite prepared by low-temperature microwave processing OssaBase^® HA (SPHA) in comparison with biological apatite, non-sintered deproteinized bovine bone Bio-Oss^® (DBB). The materials were implanted into the bone sockets of the tibia of Beagle dogs for 3 and 6 months. The bone response to granules of the materials of similar sizes was compared. Histological analysis of the specimens with histomorphometry was performed at different times after in vivo implantation. Based on the histological analysis, the level of bone formation in the spaces between the implanted granules and through the interconnected pores of both implanted materials within a cortical region was significantly higher (bone area ingrowth 72–85%) than within a cancellous bone site (bone area ingrowth 16–28%) at three and six months after implantation. According to our study, the bioactive and osteoconductive properties (bone implant contact and bone area ingrown) of the synthetic porous hydroxyapatite are very high and comparable with the biological apatite, non-sintered deproteinized bovine bone. The favourable influence of the high specific surface area and carbonate content of the synthetic, porous hydroxyapatite on bone formation was confirmed.

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Periodical:

Key Engineering Materials (Volumes 493-494)

Pages:

236-241

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.493-494.236

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Online since:

October 2011

Authors:

M. Strnadová, Z. Strnad, Pavel Šponer, Jana Jirošova, J. Strnad

Keywords:

Bone Substitute, Deproteinized Bovine Bone, Histomorphometry, Low Temperature Synthesis, Microwave Processing, Porous Hydroxyapatite

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References

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