Silver-Doped Apatite as a Bioactive and an Antimicrobial Bone Material

Article Preview

Abstract:

Phase-pure nanostructured silver-doped hydroxyapatite (nAgHA) of various Ag contents was synthesised. These nAgHA were then evaluated in-vitro using human mesenchymal stem cells (hMSCs) and Escherichia coli (E. coli). Results revealed that hMSCs grew generally well on all nAgHA at all time points. In addition, fewer E. coli were seen attaching on the surface of all nAgHA. Hence, this work demonstrated that nAgHA offers considerable potential as a biomaterial.

You might also be interested in these eBooks

Info:

Periodical:

Key Engineering Materials (Volumes 493-494)

Pages:

27-30

Citation:

Online since:

October 2011

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2012 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] K. de Groot, J.G.C. Wolke, J.A. Jansen, Calcium phosphate coatings for medical implants, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212 (1998) 137-147.

DOI: 10.1243/0954411981533917

Google Scholar

[2] A.E. Porter, N. Patel, J.N. Skepper, S.M. Best, W. Bonfeild, Effect of sintered silicate-substituted hydroxyapatite on remodelling processes at the bone-implant interface, Biomaterials 25 (2004) 3303-3314.

DOI: 10.1016/j.biomaterials.2003.10.006

Google Scholar

[3] A. Gristina, Biomaterial-centered infection: microbial adhesion versus tissue integration, Science 237 (1987) 1588-1595.

DOI: 10.1126/science.3629258

Google Scholar

[4] W. Chen, Y. Liu, H.S. Courtney, M. Bettenga, C.M. Agrawal, J.D. Bumgardner, J.L. Ong, In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating, Biomaterials 27 (2006) 5512-5517.

DOI: 10.1016/j.biomaterials.2006.07.003

Google Scholar

[5] Q.L. Feng, J. Wu, G.Q. Chen, F.Z. Cui, T.N. Kim, J.O. Kim, A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus, Journal of Biomedical Materials Research 52 (2000) 662-668.

DOI: 10.1002/1097-4636(20001215)52:4<662::aid-jbm10>3.0.co;2-3

Google Scholar