Static and Dynamic Degradation of Sintered Calcium Phosphate Ceramics

C. Newe; E. Cunningham; F. Buchanan; G. Walker; P. Prendergast; A. Lennon; N.J. Dunne

doi:10.4028/www.scientific.net/KEM.493-494.861

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494Static and Dynamic Degradation of Sintered Calcium...

Static and Dynamic Degradation of Sintered Calcium Phosphate Ceramics

Abstract:

The chemical compositions of calcium phosphate materials are similar to that of bone making them very attractive for use in the repair of critical size bone defects. The bioresorption of calcium phosphate occurs principally by dissolution. To determine the impact of composition and flow conditions on dissolution rates, calcium phosphate tablets were prepared by slip casting of ceramic slips with different ratios of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). Dissolution was evaluated at pH4 using both a static and dynamic flow regime. Both the composition of the HA:β-TCP tablet and flow regime noticeably influenced the rate of dissolution; the 50:50 HA:β-TCP composition demonstrating the greatest level of dissolution, and, exposure of the ceramic specimens to dynamic conditions producing the highest rate of dissolution. Understanding the impact of phase composition and flow condition with respect to the dissolution of calcium phosphate will aid in the development and improvement of materials for bone substitution.

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Key Engineering Materials (Volumes 493-494)

Pages:

861-865

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.493-494.861

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Online since:

October 2011

Authors:

C. Newe, E. Cunningham, F. Buchanan, G. Walker, P. Prendergast, A. Lennon, N.J. Dunne

Keywords:

Calcium Phosphate, Dissolution, Scaffold

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