In Vitro Bioactivity of Macroporous Calcium Phosphate Scaffold for Biomedical Application

Abstract:

In this study, the effects of macroporous calcium phosphate (MCP) scaffold on bioactivity as an in-vitro model has been investigated. MCP scaffold was prepared using foam replication technique by combination of ceramic and polyurethane (PU). MCP was examined by scanning electron microscope (SEM) and X-ray diffractometer (XRD) to confirm its microstructure and phase composition respectively. Bioactivity in simulated body fluid (SBF) was characterized by apatite mineralisation on MCP scaffold surface, pH, calcium (Ca²⁺) and phosphate (PO₄^3-) ion dissolution and compressive strength using universal testing machine (UTM). Experimental results showed the formation of apatite around the MCP scaffold after 30 days in SBF. pH value was gradually decreased up to 7 days and constant until 30 days. Dissolution of Ca²⁺ and PO₄^3- ion in SBF due to the occurrence of MCP degradation, hence the compressive strength are gradually decreased gradually in line with immersion period. This material may be promising for biomedical application.

• Periodical: Key Engineering Materials (Volume 705)
• Pages: 309-314
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.705.309
• Online since: August 2016
• Authors: Salina Sabudin*, Sudirman Sahid, Nor Shahida Kader Bashah, Shirin Ibrahim, Zul Hazmi Hussin, Muhamad Anas Marzuke
• Keywords: Foam Replication Technique, Scaffold, Simulated Body Fluid

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