Unique Dicarboxylate Ion Incorporation in Octacalcium Phosphate

Abstract:

Various dicarboxylate ions can be incorporated into the crystal structure of octacalcium phosphate (OCP). This unique property can be applied to develop functional bone substitute materials. However, there are many unclear points regarding the chemistry of OCP with incorporated dicarboxylate ions. In this review, we discuss the following three topics regarding the fundamental properties of OCP with incorporated dicarboxylate ions: the incorporation of two types of dicarboxylate ions into the OCP interlayer, the precise control of the interplanar spacing for OCP with dicarboxylate ions having a side chain, and the chirality recognition of guest molecules during OCP incorporation phenomena.

• Periodical: Key Engineering Materials (Volume 782)
• Pages: 3-8
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.782.3
• Online since: October 2018
• Authors: Taishi Yokoi*
• Keywords: Dicarboxylate Ions, Incorporation, Octacalcium Phosphate

References

[1] N.J. Crane, V. Popescu, M.D. Morris, P. Steenhuis, M.A. Ignelzi Jr., Raman spectroscopic evidence for octacalcium phosphate and other transient mineral species deposited during intramembranous mineralization, Bone 39 (2006) 434–442.

DOI: 10.1016/j.bone.2006.02.059

[2] O. Suzuki, H. Imaizumi, S. Kamakura, T. Katagiri, Bone regeneration by synthetic octacalcium phosphate and its role in biological mineralization, Curr. Med. Chem. 15 (2008) 305–313.

DOI: 10.2174/092986708783497283

[3] T. Kawai, S. Echigo, K. Matsui, Y. Tanuma, T. Takahashi, O. Suzuki, S. Kamakura, First clinical application of octacalcium phosphate collagen composite in human bone defect, Tissue Eng. Part A 20 (2014) 1336–1341.

DOI: 10.1089/ten.tea.2013.0508

[4] H. Monma, M. Goto, Succinate-complexed octacalcium phosphate, Bull. Chem. Soc. Jpn., 56 (1983) 3843–3844.

DOI: 10.1246/bcsj.56.3843

[5] M. Marković, B.O. Fowler, W.E. Brown, Octacalcium phosphate carboxylate. 1. Preparation and identification, Chem. Mater. 5 (1993) 1401–1405.

[6] M. Kamitakahara, H. Okano, M. Tanihara, C. Ohtsuki, Synthesis of octacalcium phosphate intercalated with dicarboxylate ions from calcium carbonate and phosphoric acid, J. Ceram. Soc. Jpn. 116 (2008) 481–485.

DOI: 10.2109/jcersj2.116.481

[7] T. Yokoi, H. Kato, I. Y. Kim, K. Kikuta, M. Kawashita, C. Ohtsuki, Synthesis of octacalcium phosphate with incorporated succinate and suberate ions, Ceram. Int. 38 (2012) 3815–3820.

DOI: 10.1016/j.ceramint.2012.01.030

[8] T. Yokoi, M. Kamitakahara, M. Kawashita, C. Ohtsuki, Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids, J. Ceram. Soc. Jpn. 121 (2013) 219–225.

DOI: 10.2109/jcersj2.121.219

[9] T. Yokoi, H. Kato, I. Y. Kim, K. Kikuta, M. Kamitakahara, M. Kawashita, C. Ohtsuki, Formation of octacalcium phosphates with co-incorporated succinate and suberate ions, Dalton Trans. 41 (2012) 2732–2737.

DOI: 10.1039/c2dt11580h

[10] T. Yokoi, M. Kamitakahara, C. Ohtsuki, Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain, Dalton Trans. 44 (2015) 7943–7950.

DOI: 10.1039/c4dt03943b

[11] T. Yokoi, S. Machida, Y. Sugahara, M. Hashimoto, S. Kitaoka, Enantioselective incorporation of dicarboxylate guests by octacalcium phosphate, Chem. Commun. 53 (2017) 6524–6527.

DOI: 10.1039/c7cc01169e