Neutral Liquid Containing Chitosan and Polyol for Calcium Phosphate Cement

Yoshiyuki Yokogawa; Kentaro Fujii; Ryota Izumiki; Seiya Shibata; Tasuku Takayasu; Hiromitsu Toyoda; Kumi Ogi; Yoshihiro Hirakawa; Akiyoshi Shimatani

doi:10.4028/www.scientific.net/KEM.782.9

Paper Titles

Unique Dicarboxylate Ion Incorporation in Octacalcium Phosphate
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Neutral Liquid Containing Chitosan and Polyol for Calcium Phosphate Cement
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Compressive Strength Evaluation and Phase Analysis of Pulp Capping Materials Based on Carbonate Apatite-SCPC Using Different Concentration of SCPC and Calcium Hydroxide
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Enzyme Immobilization Behavior on the Surface of Hydroxyapatite Capsules under Alkaline Condition
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Incorporation of Ovalbumin into Carbonate Apatite as a Candidate for Protein Delivery
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The Evaluation of Setting Time and FTIR Spectroscopy of Carbonate Apatite Cement as Endodontic Sealer
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Synthesis of Europium(III) Complex-Based Hydroxyapatite Nanocrystals for Biolabeling Applications
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HomeKey Engineering MaterialsKey Engineering Materials Vol. 782Neutral Liquid Containing Chitosan and Polyol for...

Neutral Liquid Containing Chitosan and Polyol for Calcium Phosphate Cement

Abstract:

The self-hardening calcium phosphate cement (CPC) has widely been used in bone defect repairs. CPC tends to decay or disintegrate upon early contact with blood or body fluids, and the gelation of CPC paste using sodium alginate, chitosan, or collagen may overcome such a wash-out property. The incorporation of chitosan in CPC paste increased the compressive strength and work-of-fracture. However, the viscosity of CPC paste increased with an increase of chitosan content, and acidic liquid is not favorable, as chitosan must be dissolved in an acidic solution. The CPC paste using the liquid prepared from freeze-dried chitosan powder was easily push out from the syringe, but the content of chitosan was reduced. An addition of polyol-phosphate salt to chitosan solution produces a transparent liquid at physiological pH, and the chitosan content was found to be increased. Chitosan content of liquid was increased from 0.09% to 0.54 % by adding polyol to liquid, and the compressive strength of CPC was also increased.

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Periodical:

Key Engineering Materials (Volume 782)

Pages:

9-14

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.782.9

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Online since:

October 2018

Authors:

Yoshiyuki Yokogawa*, Kentaro Fujii, Ryota Izumiki, Seiya Shibata, Tasuku Takayasu, Hiromitsu Toyoda, Kumi Ogi, Yoshihiro Hirakawa, Akiyoshi Shimatani

Keywords:

Calcium Phosphate Cement, Chitosan, Polyol

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