Insights into Drug-Loading Capacity of Bio-Zirconium Metal-Organic Frameworks Nanoparticles for Tetracycline Hydrochloride

Abstract:

The discovery of a highly efficient drug delivery system with high biocompatibility and good loading/release properties is a key challenging issue. In the past decade, metal-organic frameworks (MOFs) have shown great interest as drug delivery systems (DDSs), due to their high porosity, tunable functionality, and large drug loading capacities. Herein, we report the potential use of a new family of biocompatible MOFs called bio-MOFs synthesized from bio-based ligands and water-based synthesis for drug delivery. We propose a facile method to synthesize MIP-202 (bio-based Zr-MOF) built from Zr metal nodes and aspartic acid as an amino acid ligand. The efficiency of loading tetracycline hydrochloride drug onto MIP-202 and UiO-66-NH₂ has been carefully studied. Characterization techniques such as powder X-ray diffraction, and transmission electron microscopy have been used for structural and morphological confirmation. The loading capacity of tetracycline hydrochloride on UiO-66-NH₂ was determined to be higher than MIP-202 reaching up to 50.3%. The results provide an investigated insight into the utilization of bio-based MOFs as drug carriers for tetracycline hydrochloride.

• Periodical: Key Engineering Materials (Volume 935)
• Pages: 179-184
• DOI: https://doi.org/10.4028/p-5emz84
• Online since: November 2022
• Authors: Asmaa Ashraf Hanafi*, Marwa El-Kady, Mohamad Ayad
• Keywords: Drug Delivery, Loading Capacity, MOFs

References

[1] O. M. Yaghi, M. J. Kalmutzki, and C. S. Diercks, Introduction to reticular chemistry: metal-organic frameworks and covalent organic frameworks.

DOI: 10.1002/9783527821099

[2] A. J. Howarth, A. W. Peters, N. A. Vermeulen, T. C. Wang, J. T. Hupp, and O. K. Farha, Best practices for the synthesis, activation, and characterization of metal−organic frameworks,, Chemistry of Materials, vol. 29, no. 1. American Chemical Society, p.26–39, Jan. 10, 2017.

DOI: 10.1021/acs.chemmater.6b02626

[3] H. Furukawa, K. E. Cordova, M. O'Keeffe, and O. M. Yaghi, The Chemistry and Applications of Metal-Organic Frameworks,, Science (1979), vol. 341, no. 6149, p.1230444, 2013,.

DOI: 10.1126/science.1230444

[4] J. Lee, O. K. Farha, J. Roberts, K. A. Scheidt, S. T. Nguyen, and J. T. Hupp, Metal– organic framework materials as catalysts,, Chemical Society Reviews, vol. 38, no. 5, p.1450, 2009,.

DOI: 10.1039/b807080f

[5] N. Hanikel, M. S. Prévot, and O. M. Yaghi, MOF water harvesters,, Nature Nanotechnology, vol. 15, no. 5, p.348–355, 2020,.

DOI: 10.1038/s41565-020-0673-x

[6] Riki J. Drout, Lee Robison, Zhijie Chen, Timur Islamoglu, and Omar K. Farha, Zirconium Metal–Organic Frameworks for Organic Pollutant Adsorption,.

DOI: 10.1016/j.trechm.2019.03.010

[7] I. Abánades Lázaro and R. S. Forgan, Application of zirconium MOFs in drug delivery and biomedicine,, Coordination Chemistry Reviews, vol. 380, p.230–259, 2019,.

DOI: 10.1016/j.ccr.2018.09.009

[8] L. Wang, M. Zheng, and Z. Xie, Nanoscale metal-organic frameworks for drug delivery: A conventional platform with new promise,, Journal of Materials Chemistry B, vol. 6, no. 5. Royal Society of Chemistry, p.707–717, 2018.

DOI: 10.1039/c7tb02970e

[9] X. Chen et al., Formulation of Metal-Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility,, J Am Chem Soc, vol. 143, no. 34, p.13557–13572, Sep. 2021,.

DOI: 10.1021/jacs.1c03943.s011

[10] I. Abánades Lázaro, S. Haddad, S. Sacca, C. Orellana-Tavra, D. Fairen-Jimenez, and R.S. Forgan, Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery,, Chem, vol. 2, no. 4, p.561– 578, Apr. 2017,.

DOI: 10.1016/j.chempr.2017.02.005

[11] J. Yang, C. A. Trickett, S. B. Alahmadi, A. S. Alshammari, and O. M. Yaghi, Calcium l- Lactate Frameworks as Naturally Degradable Carriers for Pesticides,, J Am Chem Soc, vol. 139, no. 24, p.8118–8121, 2017,.

DOI: 10.1021/jacs.7b04542

[12] S. Wang et al., A robust zirconium amino acid metal-organic framework for proton conduction,, Nature Communications, vol. 9, no. 1, 2018,.

[13] S. D. Taherzade, J. Soleimannejad, and A. Tarlani, Application of metal-organic framework Nano-MIL-100(Fe) for sustainable release of doxycycline and tetracycline,, Nanomaterials, vol. 7, no. 8, Aug. 2017,.

DOI: 10.3390/nano7080215

[14] S. Rapti et al., Rapid, green and inexpensive synthesis of high quality UiO-66 amino-functionalized materials with exceptional capability for removal of hexavalent chromium from industrial waste,, Inorganic Chemistry Frontiers, vol. 3, no. 5, p.635–644, May 2016,.

DOI: 10.1039/c5qi00303b

[15] S. S. Sandhu et al., Green MIP-202(Zr) Catalyst: Degradation and Thermally Robust Biomimetic Sensing of Nerve Agents,, J Am Chem Soc, vol. 143, no. 43, p.18261–18271, Nov. 2021,.

DOI: 10.1021/jacs.1c08356.s001

[16] K. E. Diab, E. Salama, H. S. Hassan, A. Abd El-moneim, and M. F. Elkady, Biocompatible MIP-202 Zr-MOF tunable sorbent for cost-effective decontamination of anionic and cationic pollutants from waste solutions,, Scientific Reports, vol. 11, no. 1, Dec. 2021,.

DOI: 10.1038/s41598-021-86140-2

[17] Q. Qian et al., Mixed-Matrix Membranes Formed from Imide-Functionalized UiO-66-NH2 for Improved Interfacial Compatibility,, ACS Applied Materials and Interfaces, vol. 11, no. 34, p.31257–31269, Aug. 2019,.

DOI: 10.1021/acsami.9b07500

[18] A. H. Ibrahim et al., Tuning the Chemical Environment within the UiO-66-NH2 Nanocages for Charge-Dependent Contaminant Uptake and Selectivity,, Inorganic Chemistry, 2019,.

DOI: 10.1021/acs.inorgchem.9b01611.s001