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HomeKey Engineering MaterialsKey Engineering Materials Vol. 989A Novel Synthesis Route of Phenyl Quinoline from...

A Novel Synthesis Route of Phenyl Quinoline from Nitrochalcone with Hydrazine Hydrate in the Presence of Pd/C

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Abstract:

Quinoline is widely known to have many biological activities. Therefore, the development of the synthesis method of a quinoline derivative framework is a priority. A phenyl quinoline derivative, 6,7-dimethoxy-2-phenylquinoline Q1, has been successfully synthesized via a novel one-pot reaction that involves reduction, cyclization, and followed by dehydration of nitrochalcone derivate, 3-(4,5-dimethoxy-2-nitrophenyl)-1-phenylprop-2-en-1-one C1. The reaction was carried out using 80 % hydrazine hydrate in the presence of 10% Pd/C as a catalyst in an ethanol medium. Target compound Q1 was afforded in a good yield of 69.18% in a relatively short reaction time of ±2 h.

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The 5th International Conference on Chemical Sciences (ICCS)

Engineering Materials and Advanced Research: Biomedical Materials, Welding Technologies and Energy Storage

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Periodical:

Key Engineering Materials (Volume 989)

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79-86

DOI:

https://doi.org/10.4028/p-17Rfom

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Online since:

October 2024

Authors:

Nurul Hidayah*, Bambang Purwono, Ika Dyah Kumalasari

Keywords:

Hydrazine Hydrate, Nitrochalcone, Pd/C, Phenyl Quinoline

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© 2024 Trans Tech Publications Ltd. All Rights Reserved

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