Miniaturized Blood Sampling System with Integrated Sample Preparation

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Abstract:

Blood sampling as well as sample preparation are time consuming and requires a strict procedure, which is generally performed by medical trained personal. Not carrying out the procedure correctly could result in an infection of the patient or contamination of the sample itself. These limitations should be especially considered in case of pandemic outbreaks. In order to handle such a high number of patients a novel sample preparation system paired with modern blood sampling procedure is necessary. For this reason, a new device for blood sampling and preparation is designed containing an integrated microfluidic system. The fabrication is carried out by utilizing micro moulding of PDMS as well as micro milling. A first set of initial experiments as part of a first-generation study shows promising results. However, further steps of optimisation considering flow time and preparation cycle are part of a second-generation study.

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Materials Science Forum (Volume 1016)

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1280-1284

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January 2021

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© 2021 Trans Tech Publications Ltd. All Rights Reserved

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[1] Sun Min Kim et all, Cell research with physically modified microfluidic channels: A review, Lab Chip 8, (2008) 1015-1023.

Google Scholar

[2] Dhananjay Bodas, Chantal Khan-Malek, Formation of more stable hydrophilic surfaces of PDMS by plasma and chemical treatments, Microelectronic Engineering 83, (2006) 1277–1279.

DOI: 10.1016/j.mee.2006.01.195

Google Scholar

[3] W.R. Jong et all, Flows in rectangular microchannels driven by capillary force and gravity, International Communications in Heat and Mass Transfer 34 (2007) 186–196.

DOI: 10.1016/j.icheatmasstransfer.2006.09.011

Google Scholar

[4] Wentao Li et all, Squeeze-chip: a finger-controlled microfluidic flow network device and its application to biochemical assays, Lab Chip 12, (2012) 1587-1590.

DOI: 10.1039/c2lc40125h

Google Scholar

[5] V.A. Papadimitriou et all, 3D capillary stop valves for versatile patterning inside microfluidic chips, Analytica Chimica Acta 1000, (2018) 232-238.

DOI: 10.1016/j.aca.2017.11.055

Google Scholar

[6] Alain Glière, Cyril Delattre, Modeling and fabrication of capillary stop valves for planar microfluidic systems, Sensors and Actuators A 130–131, (2006) 601–608.

DOI: 10.1016/j.sna.2005.12.011

Google Scholar