Selenium Nanocluster Coatings: Transforming Current Orthopedic Materials into Inhibiting Bone Cancer

Abstract:

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Selenium (Se) nanoclusters were coated on three different orthopedic materials: Titanium, stainless steel and ultra high molecular weight polyethylene (UHMWPE). There different coating densities were achieved on each type of substrate. The uncoated and coated Ti and SS substrates were then used in experiments with either normal healthy osteoblasts (bone-forming cells) or cancerous osteoblasts (osteosarcoma) or a combination of both. For the first time, it was shown that the substrates coated with Se nanoclusters promoted (or at least maintained) normal osteoblast proliferation and inhibited cancerous osteoblast growth in both separate culture experiments and co-culture experiments. Thus, this study introduced to the orthopedic cancer community for the first time a coating material (Se) which may inhibit bone cancer growth and promote normal bone growth.

Info:

Periodical:

Materials Science Forum (Volumes 638-642)

Main Theme:

Edited by:

T. Chandra, N. Wanderka, W. Reimers , M. Ionescu

Pages:

718-723

DOI:

10.4028/www.scientific.net/MSF.638-642.718

Citation:

P. A. Tran et al., "Selenium Nanocluster Coatings: Transforming Current Orthopedic Materials into Inhibiting Bone Cancer", Materials Science Forum, Vols. 638-642, pp. 718-723, 2010

Online since:

January 2010

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Price:

$35.00

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