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Atomic Force Microscopy-Based Investigation on the Elastic Properties of Oligodendrocytes

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Abstract:

As the leading killer of human health in the current age, cancer is concerned widely in the medical profession. As the popularizations of atomic force microscopy (AFM) in micro-biology, measuring the mechanical properties of cells by AFM is gradually applied in the diagnosis and treatment of cancer. In this paper, the scanning parameters were optimized and the indentation experiments in different parts of oligodendrocytes were carried out to test the elastic modulus of oligodendrocytes. In order to evaluate the elastic modulus accurately, nine areas on each cell were selected, and for each area, a small matrix of indentation point was made. The results indicated that elastic modulus of the center part of cancer cell is softer than that in the edge, and the one of the normal cell are 3 order of magnitude harder than the cancer cell.

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Periodical:

Materials Science Forum (Volume 694)

Pages:

886-890

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.694.886

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Online since:

July 2011

Authors:

Jing He Wang, Miao Yu, Li Liu, Jie Zhao, Ying Chun Liang, Shen Dong

Keywords:

Atomic Force Microscopy (AFM), Elastic Modulus, Oligodendrocytes

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© 2011 Trans Tech Publications Ltd. All Rights Reserved

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