Synthesis of S-Licarbazepine by Asymmetric Reduction of Oxcarbazepine in Organic Solvent/Phosphate Buffer Biphasic System

Zhi Hin Ou; Jia Hui Xu

doi:10.4028/www.scientific.net/MSF.921.54

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HomeMaterials Science ForumMaterials Science Forum Vol. 921Synthesis of S-Licarbazepine by Asymmetric...

Synthesis of S-Licarbazepine by Asymmetric Reduction of Oxcarbazepine in Organic Solvent/Phosphate Buffer Biphasic System

Abstract:

S-licarbazepine was synthesized by asymmetric reduction of oxcarbazepine in organic solvent/phosphate buffer biphasic system with Bacillus anthracis CGMCC No.12337 as catalyst. Effects of many factors on reduction were studied. Dibutyl phthalate/phosphate buffer was selected as the optimal biphasic system for reduction. The optimum reduction conditions are as follows: volume ratio of dibutyl phthalate and phosphate buffer 1:1, 30 g/L iospropanol as co-substrate, phosphate buffer pH 5, substrate concentration 7.92 mmol/L, cell concentration 30 g/L, 32°C，180 rpm. The conversion and enantiometric excess of S-licarbazepine reached 97.32% and 99.80%. An efficient method for synthesis of S-licarbazepine was provided.

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Periodical:

Materials Science Forum (Volume 921)

Pages:

54-59

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.921.54

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Online since:

May 2018

Authors:

Zhi Hin Ou*, Jia Hui Xu

Keywords:

Asymmetric Reduction, Bacillus anthracis CGMCC No.12337, Dibutyl Phthalate/Phosphate Buffer Biphasic System, Oxcarbazepine, S-Licarbazepine

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