On-Chip Fabrication of None-Dead-Volume Microtips for ESI-MS Applications

Che-Hsin Lin; Jen Taie Shiea; Yen Lieng Lin

doi:10.4028/www.scientific.net/SSP.121-123.611

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HomeSolid State PhenomenaSolid State Phenomena Vols. 121-123On-Chip Fabrication of None-Dead-Volume Microtips...

On-Chip Fabrication of None-Dead-Volume Microtips for ESI-MS Applications

Abstract:

This paper proposes a novel method to on-chip fabricate a none-dead-volume microtip for ESI-MS applications. The microfluidic chip and ESI tip are fabricated in low-cost plastic based materials using a simple and rapid fabrication process. A constant-speed-pulling method is developed to fabricate the ESI tip by pulling mixed PMMA glue using a 30-μm stainless wire through the pre-formed microfluidic channel. The equilibrium of surface tension of PMMA glue will result in a sharp tip after curing. A highly uniform micro-tip can be formed directly at the outlet of the microfluidic channel with minimum dead-volume zone. Detection of caffeine, myoglobin, lysozyme and cytochrome C biosamples confirms the microchip device can be used for high resolution ESI-MS applications.

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Periodical:

Solid State Phenomena (Volumes 121-123)

Pages:

611-614

DOI:

https://doi.org/10.4028/www.scientific.net/SSP.121-123.611

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Online since:

March 2007

Authors:

Che-Hsin Lin, Jen Taie Shiea, Yen Lieng Lin

Keywords:

ESI/MS, Micro Tip, None Dead Volume, PMMA CHip

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