PEO Coated Porous Mg/HAp Implant Materials Impregnated with Bioactive Components

Abstract:

In this research the results of the formation of composite materials based on magnesium for the needs of implant surgery are discussed. The synthesis of porous magnesium with the inclusion of hydroxyapatite particles was preformed by means of a powder metallurgical mechanochemical process. The resulting samples were impregnated with bioactive additives such as shilajit. To protect against premature corrosion, the samples were coated with plasma electrolytic oxidation (PEO).

• Periodical: Solid State Phenomena (Volume 312)
• Pages: 366-371
• DOI: https://doi.org/10.4028/www.scientific.net/SSP.312.366
• Online since: November 2020
• Authors: Anatoly B. Podgorbunsky*, Igor M. Imshinetsky, Andrey S. Gnedenkov, Sergey L. Sinebryukhov, Sergey V. Gnedenkov
• Keywords: Bioactivity, Bioresorbable Implants, Hydroxyapatite, Magnesium, Personalized Medicine, Plasma Electrolytic Oxidation

References

[1] S.R. Dutta, D. Passi, P. Singh, A. Bhuibhar, Ceramic and non-ceramic hydroxyapatite as a bone graft material: a brief review, Ir. J. Med. Sci. 184 (2015) 101-106.

DOI: 10.1007/s11845-014-1199-8

[2] B.G. Barbanti, C. Griffoni, A. Nataloni, M. Manfrini, G. Giavaresi, S. Bandiera, A. Gasbarrini, S. Terzi, R. Ghermandi, G. Tedesco, M. Girolami, M. Tognon, M. Fini, Biomaterials as bone graft substitutes for spine surgery: from preclinical results to clinical study, J. Biol. Regul. Homeost. Agents 31 (2017) 167–181.

DOI: 10.1007/978-3-319-73485-9_8

[3] F.Witte, The history of biodegradable magnesium implants: a review, Acta Biomater. 6 (2010) 1680–92.

[4] M.P. Staiger, A.M. Pietak, J. Huadmai, G. Dias, Magnesium and its alloys as orthopedic biomaterials: a review, Biomaterials. 27 (2006) 1728–34.

DOI: 10.1016/j.biomaterials.2005.10.003

[5] R. Zeng, W. Dietzel, F. Witte, N. Hort, C. Blawert, Progress and challenge for magnesium alloys as biomaterials, Adv Eng Mater. 10 (2008) B3–B14 [+702].

DOI: 10.1002/adem.200800035

[6] F. Witte et al., Degradable biomaterials based on magnesium corrosion, Curr Opin Solid State Mater Sci. 12 (2008) 63–72.

[7] J.L. Workinger, R.P. Doyle and J. Bortz, Challenges in the Diagnosis of Magnesium Status, Nutrients. 10(9) (2018) 1202.

DOI: 10.3390/nu10091202

[8] H. Hornberger, S. Virtanen A.R. Boccaccini, Biomedical coatings on magnesium alloys – A review, Acta Biomaterialia. 8 (2012) 2442–2455.

DOI: 10.1016/j.actbio.2012.04.012

[9] S.V. Gnedenkov, S.L. Sinebryukhov, V.S. Egorkin, D.V. Mashtalyar, I.E. Vyaliy, K.V. Nadaraia, I.M. Imshinetskiy, A.I. Nikitin, E.P. Subbotin, A.S. Gnedenkov, Magnesium fabricated using additive technology: Specificity of corrosion and protection, J. Alloys Compd. 808 (2019) 151629.

DOI: 10.1016/j.jallcom.2019.07.341

[10] Ali, F. Iqbal, A. Ahmad F. Ikram et al., Hydrothermal deposition of high strength calcium phosphate coatings on magnesium alloy for biomedical applications, Surf. Coat. Technol. 357 (2019) 716–727.

DOI: 10.1016/j.surfcoat.2018.09.016

[11] Kucharczyk, K. Naplocha, J.W. Kaczmar, H. Dieringa and K.U. Kainer. Current Status and Recent Developments in Porous Magnesium Fabrication, Adv. Eng. Mater. 20 (2018) 1–16.

DOI: 10.1002/adem.201700562

[12] S. Liu, C. Zhou, S. Mou, J. Li, M. Zhou, Y. Zeng, C. Luo, J. Sun, Z. Wang, W. Xu, Biocompatible graphene oxide–collagen composite aerogel for enhanced stiffness and in situ bone regeneration, Materials Science & Engineering C. 105 (2019) 110137.

DOI: 10.1016/j.msec.2019.110137

[13] I. Schepetkin, A. Khlebnikov and B.S. Kwon, Medical Drugs From Humus Matter: Focus on Mumie, Drug development research. 57 (2002) 140–159.

DOI: 10.1002/ddr.10058

[14] S. Agarwal, J. Curtin, B. Duffy, S. Jaiswal. Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications, Mater. Sci. Eng., C. 68 (2016) 948–963.

DOI: 10.1016/j.msec.2016.06.020

[15] A.B. Podgorbunsky, K.V. Nadaraia, I.M. Imshinetsky, S.L. Sinebryukhov and S.V. Gnedenkov. Formation on magnesium alloy MA8 bioactive coatings containing nanosized hydroxyapatite, J. Phys. Conf. Ser. 1092 (2018) 1–4.

DOI: 10.1088/1742-6596/1092/1/012117

[16] A.B. Podgorbunsky, O.O. Shichalin, S.V. Gnedenkov, Composite materials based on magnesium and calcium phosphate compounds, Materials Science Forum. 992 (2020) 796–801.

DOI: 10.4028/www.scientific.net/msf.992.796

[17] A.S. Gnedenkov, D. Mei, S.V. Lamaka, S.L. Sinebryukhov, D.V. Mashtalyar, I.E. Vyaliy, M.L. Zheludkevich, S.V. Gnedenkov, Localized currents and pH distributionstudied during corrosion of MA8 Mg alloy in the cell culture medium, Corros. Sci. (2020) (accepted).

DOI: 10.1016/j.corsci.2020.108689