Evaluation of the Influence of Ferrite Magnetic Nanoparticle for Cancer Cell

Abstract:

Magnetic nanoparticles for thermotherapy must be biocompatible and possess high thermal efficiency as heating elements. The biocompatibility of Mg_0.8Ni_0.2Fe₂O₄ nanoparticles was studied using a cytotoxicity colony formation assay and a cell viability assay. HeLa cells exhibited cytotoxic effects when exposed to three different concentrations of 150 μg/ml, 100 μg/ml, and 50 μg/ml nanoparticles. Therefore, concentrations of 50 μg/ml showed the lowest cytotoxic activity and the lowest toxicity to living cells. In vitro cytotoxicity of samples was then investigated by two methods, colony formation assay and cell viability assay. The Hela inhibited cell growth as 16.8% during heating by magnetic field generators.

• Periodical: Solid State Phenomena (Volume 323)
• Pages: 146-151
• DOI: https://doi.org/10.4028/www.scientific.net/SSP.323.146
• Online since: August 2021
• Authors: Khishigdemberel Ikhbayar*, Nomin Myagmar, Gantulga Davaakhuu, Uyanga Enkhnaran, Enkhmend Bekhbaatar, Narmandakh Jargalan, Oyunsuren Tsendsuren, Sangaa Deleg
• Keywords: Crystal Structure, Cytotoxic Activity, Ferrite, Hela Cells

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