Response surface methodology (RSM) was adopted to study the key parameters such as activation temperature, activation time, and active agent amount in order to increase activated carbon iodine adsorption value from rice husk. A second order quadratic equation was established and the applicability of model and interaction involved factors on predicting the iodine adsorption value was verified. The results indicated that the effect on the iodine adsorption value was as follows: activation temperature, activation ratio, activation time. The optimal levels for achieving the highest iodine adsorption value were obtained, including activation temperature of 550°C, activation time of 48min and activation ratio of 1.25. The iodine adsorption value reached 1464.793mg/g under optimized conditions. Iodine adsorption value was conducted under the optimum condition and the results showed the average relative error 0.58%, it proved that the models fitted well, the experimental data and the model were feasible.