Biodegradable Polymers as Matrices for Control Drug Delivery

Abstract:

In the paper the results of control drug release from different forms of carriers are presented. Dibutyrylchitin, chitosan, polylactid acid and polycaprolactone have been used as matrices for delivery of therapeutic substances (ibuprofen and salicylic acid). Two configurations of matrices for drug delivery have been found. Flat drug delivery systems (films) and spherical matrices (beads) were tested in the aim of control drug transport. To control the drug release, matrices have been modified. The release of active substances from films has been tested in buffer solution of pH 5.5. Spherical matrices have been tested in buffer solutions of pH 1.4 and pH 7.2. To experimental data First order and two stage models were fitted.

• Periodical: Advanced Materials Research (Volume 911)
• Pages: 336-341
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.911.336
• Online since: March 2014
• Authors: Maria Mucha*, Iwona Socha-Michalak, Jacek Balcerzak
• Keywords: Biodegradable Polymers, Chitosan, Control Release, Dibutyrylchitin, Drug Delivery, Ibuprofen, Polycaprolactone, Polylactid Acid, Salicylic Acid

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