Smart Mesoporous Silica Nanocomposite for Triggered and Targeted Ibuprofen Drug Delivery

Bhasker Pant; Sheetal Mujoo; Shaikh Rajesh Ali; Vasu Gajendiran; Larissa Souza Amaral; Mohammad Mobarak Hossain

doi:10.4028/p-hx82v3

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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 117Smart Mesoporous Silica Nanocomposite for...

Smart Mesoporous Silica Nanocomposite for Triggered and Targeted Ibuprofen Drug Delivery

Abstract:

Mesoporous silica nanocomposite (MSNC) with a wall thick of around 10 nm were created using Fe₃O₄ nanoparticles as the inorganic template. In accordance with the results of SEM and BET analysis, MSNC were homogenous spherical particles with good dispersion, and their specific surface area it possible that Ibuprofen will become stuck within the MSNC carrier. Loading of drug shows a decline in a surface area from 225.08 to 69.25 m² g^-1, pore volume from 0.56 to 0.13cm g^-1 and the pore diameter from 7.96 to 6.74 nm correspondingly. The amount of Ibuprofen entrapped in the carrier was measured by UV spectroscopy and total glycerol (TG) measurement, respectively. It was determined pore size distribution of MSNC changed before and after Ibuprofen entrapment. The release profile of Ibuprofen from MSNC was characterised by a three-stage pattern with an influence on the time between each stage.

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Advances in Science and Technology (Volume 117)

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111-115

DOI:

https://doi.org/10.4028/p-hx82v3

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Online since:

August 2022

Authors:

Bhasker Pant, Sheetal Mujoo, Shaikh Rajesh Ali, Vasu Gajendiran, Larissa Souza Amaral*, Mohammad Mobarak Hossain

Keywords:

Drug Delivery, Ibuprofen, Porous Nanocomposite, Silica

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