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Zinc(II) Mixed Ligand Complexes of Acesulfame and Thiones: Structural Characterization and Biological Activity

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Abstract:

Acesulfame, with its oxathiazinone ring and potential coordination sites, acts as a ligand in forming complexes with various metal ions. According to this point, this study includes the synthesis and characterization of novel zinc(II) complexes incorporating acesulfame (acs) with various thione-containing ligands: 2-mercaptobenzothiazole (bztSH), 2-mercapto-benzimidazole (bizmSH), 2-mercaptobenzoxazole (bzoxSH), 1,3-dihydro-2H-imidazole-2-thione (imSH), and 5-(p-tolyl)oxazole-2(3H)-thione (mphtSH). The synthesized complexes, identified as [Zn(acs)₂(bztSH)₂] (1), [Zn(acs)₂(bizmSH)₂] (2), [Zn(acs)₂(bzoxSH)]₂ (3), [Zn(acs)₂(imSH)₂] (4), and [Zn(mphtS)₂] (5), were structurally elucidated using CHN analysis, nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy, and molar conductivity measurements. Results indicate that the acesulfame ligand coordinates as a monodentate ligand via its nitrogen atom in complexes (1-4). In complex (1), the bztSH ligand coordinates in a monodentate mode through the nitrogen atom of its heterocyclic ring. Conversely, in complexes (2) and (4), bizmSH and imSH coordinate as monodentate ligands via their sulfur atoms. Complex (3) is a binuclear species where bzoxSH coordinates as a bidentate ligand through both its nitrogen and sulfur atoms. Notably, in complex (5) , the mphtSH ligand displaces acesulfame, coordinating as a bidentate ligand through its nitrogen and sulfur atoms. Furthermore, the antibacterial activities of these complexes were evaluated against Staphylococcus aureus and Escherichia coli. Complexes (4) and (1) demonstrated the highest efficacy. The [Zn(acs)₂(imSH)₂] (4) exhibited inhibition efficiencies of 74% and 79% with inhibition zones of 20 mm and 23 mm against S. aureus and E. coli, respectively. Similarly, [Zn(acs)₂(bztSH)₂] (1) showed inhibition efficiencies of 70% and 76% with inhibition zones of 19 mm and 22 mm against S. aureus and E. coli, respectively.

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Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 71 View Preview

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Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 71)

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17-32

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https://doi.org/10.4028/p-ab3Xvf

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Online since:

February 2026

Authors:

Marwa R. Dawood, Ahmed S. M. Al-Janabi*, Ahmed S. Faihan

Keywords:

Acesulfame, Biological Activity, Complexes, Thione, Zinc

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© 2026 Trans Tech Publications Ltd. All Rights Reserved

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