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New Trends in Enhancing Biological Efficacy and Safety of Proton Therapy: State of Art and Prospective
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Development and Testing of Components for Combined Cancer Treatment in Strongly Localized Therapy: Georgian Experience
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Development and Testing of Components for Combined Cancer Treatment in Strongly Localized Therapy: Georgian Experience

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Abstract:

Cancer and cardiovascular diseases are the leading causes of global morbidity and mortality, being in 2023 responsible for about 24 and 35% of deaths, respectively. In addition, they reveal a bidirectional association and demonstrate a significant super-additive impact on each other. Combination therapy of cancer effectively targets and affects pathways that play important roles in causing and sustaining malignant cell induction and progression. Alkali metal solutions are among the intensively studied anticancer agents, whereas cesium chloride is a popular alternative highly consumed anticancer BAD. The results reported clearly show that rubidium chloride solution reveals the highest biological efficacy and selectivity to cancer cells among the four types of tested samples, which is rather difficult to interpret in the frame of the cancer high-pH therapy concept. This is why the next stage of the research should be focused on the measuring the alkalinity and cesium content in the intracellular area of the exposed cells.

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Computational Research and Modeling in Materials Science and Materials Application View Preview

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Periodical:

Key Engineering Materials (Volume 1029)

Pages:

123-132

DOI:

https://doi.org/10.4028/p-pOwy4B

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Online since:

November 2025

Authors:

Archil Chirakadze*, Nana Khuskivadze, Irakli Nadiradze, Zakaria Buachidze

Keywords:

Anticancer Treatment Efficacy and Safety, Cell Apoptosis and Viability, High-pH Therapy Concept, MTT Testing, Non-Small Cell Lung Cancer, Strongly Localized Combination Cancer Therapy

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© 2025 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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