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Surface Wettability Enhances Osteoblast Adhesion on Silicon-Substituted Hydroxyapatite Thin Films

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Abstract:

Crystalline hydroxyapatite (HA) and 0.8 wt.% silicon-substituted HA (SiHA) thin films were produced using magnetron co-sputtering. These films were subjected to contact angle measurements and in vitro cell culture study using human osteoblast-like (HOB) cells. A wettability study showed that SiHA has a lower contact angle, and thus is more hydrophilic in nature, as compared to HA. Consequently, enhanced cell growth was observed on SiHA at all time-points. Furthermore, distinct and well-developed actin filaments could be seen within HOB cells on SiHA. Thus, this work demonstrated that the surface properties of the coating may be modified by the substitution of Si into the HA structure.

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Bioceramics 19 View Preview

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

877-880

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.877

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Online since:

February 2007

Authors:

E.S. Thian, J. Huang, Serena Best, Zoe H. Barber, William Bonfield

Keywords:

Hydroxyapatite (HAP), Magnetron Sputtering, Osteoblast, Silicon, Surface Wettability

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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