Release of All-Trans Retinoic Acid (RA) from RA-Loaded Poly(Ester Amine) Based on Polyethylenimine and Polycaprolactone for Intracellular Delivery

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The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

429-432

Citation:

D. D. Guo et al., "Release of All-Trans Retinoic Acid (RA) from RA-Loaded Poly(Ester Amine) Based on Polyethylenimine and Polycaprolactone for Intracellular Delivery", Key Engineering Materials, Vols. 342-343, pp. 429-432, 2007

Online since:

July 2007

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$41.00

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