Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Abstract:

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Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

433-436

DOI:

10.4028/www.scientific.net/KEM.342-343.433

Citation:

H. L. Jiang et al., "Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro", Key Engineering Materials, Vols. 342-343, pp. 433-436, 2007

Online since:

July 2007

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Price:

$35.00

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