Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Hu Lin Jiang; Rohidas B. Arote; Ji Shan Quan; Mi Kyong Yoo; You Kyoung Kim; In Yong Kim; Zhong Shan Hong; Hong Gu Lee; Xun Jin; Yun Jaie Choi; Chong Su Cho

doi:10.4028/www.scientific.net/KEM.342-343.433

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 342-343Alginate-Coated Thiolated Chitosan Microspheres...

Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Abstract:

Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.

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Key Engineering Materials (Volumes 342-343)

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433-436

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.433

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Online since:

July 2007

Authors:

Hu Lin Jiang, Rohidas B. Arote, Ji Shan Quan, Mi Kyong Yoo, You Kyoung Kim, In Yong Kim, Zhong Shan Hong, Hong Gu Lee, Xun Jin, Yun Jaie Choi, Chong Su Cho

Keywords:

Alginate, Bovine Growth Hormone, Mucoadhesive, Oral Drug Delivery System, Thiolated Chitosan Microsphere

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