Characterization of Bio-Absorbable and Biomimetic Apatite/Collagen Composite Powders Derived from Fish Bone and Skin by the Dissolution-Precipitation Method

Toshiyuki Akazawa; Masaru Murata; M. Ito; Shunji Iida; Tatsuhiro Shigyo; Takafumi Nomura; Hiroyuki Inano; Tohru Yamagishi; Kohji Itabashi; Katsuo Nakamura

doi:10.4028/www.scientific.net/KEM.493-494.114

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Characterization of Bio-Absorbable and Biomimetic Apatite/Collagen Composite Powders Derived from Fish Bone and Skin by the Dissolution-Precipitation Method
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494Characterization of Bio-Absorbable and Biomimetic...

Characterization of Bio-Absorbable and Biomimetic Apatite/Collagen Composite Powders Derived from Fish Bone and Skin by the Dissolution-Precipitation Method

Abstract:

Bio-absorbable and biomimetic composites (HA-C) of hydroxyapatite (HAp) and collagen were designed utilizing salmon bone and skin at 298K and pH 7.5-7.9 by a dissolution-precipitation method. The HA-C powders were consistuted by Ca²⁺-deficient HAp containing small amounts of Na⁺ and Mg²⁺ ions and I type-collagen. Microstructure and surface characteristics of the HA-C powders gradually changed depending on the composition ratio of HAp to collagen (H/C). The HA-C powder of H/C=3.5 had frock like-agglomerated particles consisted of nano-crystals, micro-pore, and meso-pore so that it exhibited high specific surface area (75m²¥g^-1) and large total pore volume (0.543 cm³¥g^-1). From adsorption isotherms of water vapor at 298K for the HA-C powders, hysteresis - curves of the amounts of water vapor adsorbed were obtained in the adsorption-desorption processes. The amounts of water vapor adsorbed for the H/C=3.5 powder were the highest values under the relative partial pressures of 0.73-0.93. At 2 weeks after implantation of the HA-C powders into the subcutaneous tissue of the back region in rats, collagen was completely bio-absorbed and body fluid permeated into large agglomerated particles, although bio-absorption by multi-giant cell- infiltration was recognized around the surface layers of HAp particles.

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Periodical:

Key Engineering Materials (Volumes 493-494)

Pages:

114-119

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.493-494.114

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Online since:

October 2011

Authors:

Toshiyuki Akazawa, Masaru Murata, M. Ito, Shunji Iida, Tatsuhiro Shigyo, Takafumi Nomura, Hiroyuki Inano, Tohru Yamagishi, Kohji Itabashi, Katsuo Nakamura

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Bio-Absorption, Biomimetic Materials, Collagen, Composite, Dissolution-Precipitation, Hydroxyapatite (HAP), Marine Resources

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