The Antiarrhythmic Effect of 4-Methyl-2,6-Diisobornylphenol in Myocardial Ischemia/Reperfusion

Tatyana Plotnikova; Mark Plotnikov; Galina Chernysheva; Vera Smol'yakova; Pyotr P. Shchetinin; Aleksandr Kuchin; Irina Chukicheva

doi:10.4028/www.scientific.net/KEM.683.469

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 683The Antiarrhythmic Effect of...

The Antiarrhythmic Effect of 4-Methyl-2,6-Diisobornylphenol in Myocardial Ischemia/Reperfusion

Abstract:

We studied the antiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6- diisobornylphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality of animals. Dibornol (p.o. administration 100 mg/kg 24 and 3 hours before ischemia) did not change the frequency and kinds of arrhythmia in acute ischemia, but significantly reduced the frequency and the level of seriousness of arrhythmia in the reperfusion period, decreased the mortality of rats due to lethal arrhythmia.

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Key Engineering Materials (Volume 683)

Pages:

469-474

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.683.469

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Online since:

February 2016

Authors:

Tatyana Plotnikova, Mark Plotnikov, Galina Chernysheva, Vera Smol'yakova, Pyotr P. Shchetinin*, Aleksandr Kuchin, Irina Chukicheva

Keywords:

4-Methyl-2,6-Diisobornylphenol, Antiarrhythmic Activity, Antioxidant, Ischemia, Lipid Peroxidation, New Pharmaceutical Materials, Reperfusion

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References

[1] World Health Statistics 2014: Indicator compendium, World Health Organization, Geneva, (2015).

Google Scholar

[2] T.M. Kolettis, Coronary artery disease and ventricular tachyarrhythmia: pathophysiology and treatment, Curr. Opin. Pharmacol. 13 (2013) 1-8.

Google Scholar

[3] M.E.M. Garzon, M.B. Miller, S. Borzak, L. Tamariz, Early repolarization and risk for ventricular arrhythmias in patients with coronary artery disease: a meta-analysis, J. Amer. College of Cardiology. 63 (2014) DOI: 10. 1016/S0735-1097(14)60335-1.

DOI: 10.1016/s0735-1097(14)60335-1

Google Scholar

[4] J. Lønborg, N. Vejlstrup, H. Kelbæk, H.E. Bøtker, W.Y. Kim, A.B. Mathiasen, T. Engstrøm, Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction, Eur. Heart J. 12 (2012) 1491-1499.

DOI: 10.1093/eurheartj/ehr309

Google Scholar

[5] E. Kleina, V. Lukesb, Z. Cibulkova, On the energetics of phenol antioxidants activity, Petroleum and Coal. 1 (2005) 33-39.

Google Scholar

[6] S. Fujisawa, Y. Kadoma, I. Yokoe, Radical-scavenging activity of butylated hydroxytoluene (BHT) and its metabolites, Chem. Phys. Lipids. 2 (2004) 189-195.

DOI: 10.1016/j.chemphyslip.2004.03.005

Google Scholar

[7] T.M. Plotnikova, G.A. Chernysheva, V.I. Smol'yakova, P.P. Shchetinin, A.V. Kuchin, I.Y. Chukicheva, M.B. Plotnikov, Hemorheologic Effects of dibornol in a model of myocardial ischemia/reperfusion, Bull. Exp. Biol. Med. 157(2) (2014) 211-214.

DOI: 10.1007/s10517-014-2527-8

Google Scholar

[8] A.N. Mironov, A.N. Bunatyan, Guide to experimental (preclinical) study of new pharmacological substances, Moscow [in Russian], (2013).

Google Scholar

[9] X. He, M. Zhao, X.Y. Bi, Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: role of ROS and eNOS, Lab. Invest. 93 (2013) 168-180.

DOI: 10.1038/labinvest.2012.160

Google Scholar

[10] W. Davis Prophylactic Antioxidant use for the Prevention of Post-Operative Atrial Fibrillation in Cardiac Surgery Patients, Pacific University Common Knowledge, 2014, Available at: http: /commons. pacificu. edu/cgi/viewcontent. cgi?article=1504&context=pa.

Google Scholar

[11] N. Fillmore, J. Mori, G.D. Lopaschuk Mitochondrial fatty acid oxidation alterations in heart failure, ischemic heart disease and diabetic cardiomyophaty, Br J Pharmacol. 8 (2014) 2080-(2090).

DOI: 10.1111/bph.12475

Google Scholar