Preparation of Biocompatible Composites based on Poly-L-Lactide/Hydroxyapatite and Investigation of their Anti-Inflammatory Activity

Elena Shapovalova; Darya Lytkina; Liudmila Rasskazova; Ilya Zhuk; Alexandru Gudima; Anatoly Filimoshkin; Natalya Korotchenko; Irina Kurzina; Julia Kzhyshkowska

doi:10.4028/www.scientific.net/KEM.683.475

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 683Preparation of Biocompatible Composites based on...

Preparation of Biocompatible Composites based on Poly-L-Lactide/Hydroxyapatite and Investigation of their Anti-Inflammatory Activity

Abstract:

Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of anti-inflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites

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Periodical:

Key Engineering Materials (Volume 683)

Pages:

475-480

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.683.475

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Online since:

February 2016

Authors:

Elena Shapovalova, Darya Lytkina, Liudmila Rasskazova, Ilya Zhuk, Alexandru Gudima, Anatoly Filimoshkin, Natalya Korotchenko, Irina Kurzina, Julia Kzhyshkowska

Keywords:

Biocompatibility, Biocomposite Material, Cytokines, Hydroxyapatite, Macrophages, Monocytes, Polylactic Acid

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