Screening of the Promising Phytogenic Medicinal Materials among the Plant Species of Altai Flora by Supercritical Fluid Extraction

Abstract:

The increase of bacterial resistance to synthobiotics makes it relevant to search for new medicinal materials with antibiotic properties. Antimicrobials based on plants represent a huge untapped source of medicines. Antibiotic properties of 34 plant species of Altai flora are studied in this paper. Extracts from plants were obtained by supercritical fluid extraction using supercritical carbon dioxide. Antimicrobial activity of these extracts was determined by micromethod of serial dilutions in liquid media. Escherichia coli XL-1 blue and Staphylococcus aureus 209 strains were used as test-cultures. Upon the results of the study, the extracts from raw material of Penthaphylloides fruticosa and Ribes nigrum can be considered as the most promising for further pharmacological evaluation as new medicinal materials

• Periodical: Key Engineering Materials (Volume 683)
• Pages: 481-486
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.683.481
• Online since: February 2016
• Authors: Maria Krasnoborodkina, Maria Ivanova*, Maxim Kutsev
• Keywords: Antibacterial Activity, E. coli, Phytogenic Medicinal Materials, S. aureus, Supercritical Fluid CO₂-Extracts

References

[1] E.A. Zy, A. Area, K. Aam, Antimicrobial activity of some medicinal plant extracts in Palestine, Pak. J. Med. Sci. 21 (2005) 187-193.

[2] J. Davies, D. Davies, Origins and evolution of antibiotic resistance, Microbiol. Mol. Biol. Rev. 74(3) (2010) 417-433.

DOI: 10.1128/mmbr.00016-10

[3] S.B. Levy, Antibiotic resistance, consequences of inaction, Clin. Infect. Dis. 33 (Supplement 3) (2001) 124-129.

[4] B. Spellberg, R. Guidos, D. Gilbert, J. Bradley, H.W. Boucher, W.M. Scheld, J.G. Bartlett, J. Edwards Jr, The infectious diseases society of America the epidemic of antibiotic-resistant infections, a call to action for the medical community from the infectious diseases society of America, Clin. Infect. Dis. 46 (2) (2008).

DOI: 10.1086/524891

[5] R.L. Finley, P. Collignon, D.G.J. Larsson, S.A. McEwen, X. -Z. Li, W.H. Gaze, R. Reid-Smith, M. Timinouni, D.W. Graham, E. Topp, The scourge of antibiotic resistance: the important role of the environment, Clin. Infect. Dis. 57 (5) (2013) 704-710.

DOI: 10.1093/cid/cit355

[6] European Centre for Disease Prevention and Control (ECDC), European Medicines Agency (EMEA), Joint technical report: the bacterial challenge. Time to react (ECDC–EMEA, Stockholm, 2009).

[7] M. Chen, Antimicrobial resistance in the European Union and the world, The EU's contributions to the solutions of the global antimicrobial resistance problem Keynote address at the conference on Combating antimicrobial resistance: time for action (Copenhagen, Denmark, 14 March 2012).

[8] Register of Medical Plants of Russia, fifth ed., Moscow, (1998).

[9] Yu.V. Shinkarenko, Secondary metabolites of representatives of family Boraginaceae Juss. in connection with the taxonomy and biological activity: thesis abstract, Novosibirsk, (2007).

[10] P.Y. Chunga, L.Y. Chunga, Y.F. Ngeow, S.H. Goh, Z. Imiyabir, Antimicrobial activities of Malaysian plant species, Pharm. Biol. 42 (2004) 292-300.

DOI: 10.1080/13880200490511837

[11] R. Nair, S.V. Chanda, Antibacterial activity of some medicinal plants of Saurashtra region, J. Tissue Res. 4 (2004) 117-120.

[12] H.J. De Boer, A. Kool, A. Broberg, W.R. Mziray, I. Hedberg, J.J. Levenfors, Antifungal and antibacterial activity of some herbal remedies from Tanzania, J. Ethnopharmacol. 96 (2005) 461-469.

DOI: 10.1016/j.jep.2004.09.035

[13] R. Nair, T. Kalariya, S. Chanda, Antibacterial activity of some selected Indian medicinal flora, Turk. J. Biol. 29 (2005) 41-47.

[14] I.N. Zilfikarov, V.A. Chelombit'ko, A.M. Aliev, Processing of Medicinal Plants Using Liquefied Gases and Supercritical Fluids, Pyatigorsk, (2007).

[15] E.F. Veslopolova, The micro-method of determine the number of colony-forming microorganisms, Microbiology. 64(2) (1995), 279-284.

[16] Determination of the sensitivity of microorganisms to antibiotics (Methodical instructions of MUK 4. 2. 1890-04), Clinical Microbiology Antimicrobial Chemotherapy. 6(4) (2004) 306-359.

[17] A.S. Labinskaya, Microbiology with the technique of microbiological tests, Medicine, (1978).

[18] A.V. Romanov, A.V. Dekhnich, M.V. Eidelstein, Molecular epidemiology of Staphylococcus aureus strains in children's hospitals of Russia, Clinical microbiological antimicrobial chemotherapy. 14 (3) (2012) 201-208.

[19] S.N. Rampersad, Multiple applications of Alamar Blue as an indicator of metabolic function and cellular health in cell viability bioassays, Sensors. 12 (2012) 12347-12360.

DOI: 10.3390/s120912347

[20] N.M. Makarchuk, Ya.S. Leshchinskaya, Yu.A. Akimov, Phytoncides in Medicine, Kiev, (1990).

[21] S.V. Sidorenko, The clinical significance of microbial resistance to antimicrobial agents, Russian medical lead. 1 (1998) 28-34.

[22] A.J. Vlietinck, L. van Hoof, J. Totte, A. Lasure, D. Vanden Berghe, P.C. Rwangabo, J. Mvukiyumwami, Screening of hundred Rwandese medicinal plants for antimicrobial and antiviral properties, J. Etyhnopharmacol. 46 (1995) 31-47.

DOI: 10.1016/0378-8741(95)01226-4

[23] T. Rabe, J. van Staden, Antibacterial activity of South African plants used for medicinal purposes, J. Ethnopharmacol. 56 (1997) 81-87.

DOI: 10.1016/s0378-8741(96)01515-2