Role of Inflammation, Viruses and Tissue Macrophages in the Development of Idiopathic Arrhythmia and Heart Failure

Abstract:

Endomyocardial biopsy is the gold standard in the diagnosis of myocardial pathology. Intravital study of endomyocardial samples offers the possibility to determine the morphological substrate and etiology of disease, to monitor the effectiveness of treatment. We studied morphological features, viral antigens, macrophages and specifically alternatively activated macrophages in endomyocardial biopsies of 25 patients with idiopathic arrhythmias and heart failure. Immunohistological study was performed to identify type of lymphocytes, macrophages and antigens of cardiotropic viruses. We observed the presence of alternatively activated macrophages in myocardium of patients with myocarditis and without it. We detected the presence of viral antigens in the myocardium of patients with myocardial fibrosis without of histological criteria myocarditis. Small focal infiltration of the myocardial CD68+ macrophages associated with heart failure and ventricular arrhythmias. The presence of virus antigens in myocardium associated with fewer myocardial stabilin-1+ macrophages [negative correlation]. On the other side small focal infiltration of stabilin-1+ macrophages correlated with severity of myocardial interstitial fibrosis [positive correlation]

• Periodical: Key Engineering Materials (Volume 683)
• Pages: 487-492
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.683.487
• Online since: February 2016
• Authors: Yuliya Rogovskaya*, Roman Botalov, Vyacheslav Ryabov, Mariya Rebenkova, Rostislav Karpov, Sergey Popov, Julia Kzhyshkowska
• Keywords: Cardiotropic Viruses, Endomyocardial Biopsy, Macrophages, Myocarditis

References

[1] Y. Rogovskaya, R. Botalov, V. Ryabov, Histopathologic, immunohistochemical features and profile of viral antigens in patients with myocarditis, Advanced Materials Research 1085 (2015) 447-452.

DOI: 10.4028/www.scientific.net/amr.1085.447

[2] R.E. Batalov, Y.V. Rogovskaya, V.V. Ryabov, R.B. Tatarsky, S.I. Sazonova, M.S. Khlynin, S.V. Popov, R.S. Karpov, Idiopathic form of atrial fibrillation, inflammation and clinical results of radiofrequency ablation, Russ. J. Cardiol. 116 (2014).

DOI: 10.15829/1560-4071-2014-12-7-12

[3] H. Wang, Q. Yao, S. Zhu, G. Zhang, Z. Wang, Z. Li, R. Sun, C. Lu, C. Li, J. Pu, The autopsy study of 553 cases of sudden cardiac death in Chinese adults, Heart and Vessels 29 (2014) 486-95.

DOI: 10.1007/s00380-013-0388-0

[4] A.L.P. Caforio, R. Marcolongo, R. Jahns, M. Fu, S.B. Felix, S. Iliceto, Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management, Heart Fail Rev. 60 (2013) 715-732.

DOI: 10.1007/s10741-012-9364-5

[5] J. Kzhyshkowska, Multifunctional receptor stabilin-1 in homeostasis and disease, The Scientific World Journal 10 (2010) 2039–(2053).

DOI: 10.1100/tsw.2010.189

[6] K. Morizono, I.S.Y. Chen, Role of phosphatidylserine receptors in enveloped virus infection, Journal of Virology 88 (2014) 4275–4290.

DOI: 10.1128/jvi.03287-13

[7] D.L. Fairweather, D. Cihakova, Alternatively activated macrophages in infection and autoimmunity, J. Autoimmun. 33 (2009) 222–230.

DOI: 10.1016/j.jaut.2009.09.012

[8] B. Maisch, B. Bultman, S. Factor, et al, World Heart Federation consensus conferences' definition of inflammatory cardiomyopathy (myocarditis): report from two expert committees on histology and viral cardiomyopathy, Heart beat 4 (1999) 3-4.

[9] C. Basso, F. Calabrese, A. Angelini, E. Carturan, G. Thiene, Classification and histological, immunohistochemical, and molecular diagnosis of inflammatory myocardial disease, Heart Fail Rev. 18 (2013) 673-681.

DOI: 10.1007/s10741-012-9355-6