Magnetic Nanoparticles Inclusion into Scaffolds Based on Calcium Phosphates and Biopolymers for Bone Regeneration

Abstract:

Considering its functions (support, protection, assisting in movement and storage of minerals), the bone is an essential organ for the human body and the bone trauma/damages have a great impact on the human body functionality. For that reason a variety of biomaterials are studied for potential applications in bone regeneration or substitution. Bone substitution materials, with similar chemical composition to that of natural bone, and specifically those obtained by processes which mimic the natural bone formation in vivo, has been shown to be among the best. In this study, using a process of co-precipitation of calcium phosphate precursors on a mixture of biopolymers (chitosan, collagen, hialuronic acid) and magnetic nanoparticles (magnetite functionalized with chitosan), biodegradable biomimetic scaffolds have been obtained. In order to study their chemical structure, the biodegradable scaffolds have been characterized by Fourier Transform Infrared Spectroscopy (FTIR). The morphology of the biodegradable scaffolds, studied using scanning electron microscopy (SEM) indicated a macroporous morphology, which influenced the retention of simulated biological fluids. A direct relationship between the scaffolds’ degradation rate and the concentration of the polymeric phase has been observed. The in vitro cytocompatibility tests indicate that the prepared scaffolds are biocompatible and assure and adequate mediums for osteoblasts.

• Periodical: Key Engineering Materials (Volume 745)
• Pages: 16-25
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.745.16
• Online since: July 2017
• Authors: Florina Daniela Ivan, Vera Balan, Maria Butnaru, Ionel Marcel Popa, Liliana Verestiuc*
• Keywords: Biopolymers, Bone Regeneration, Calcium Phosphates, Magnetic Nanoparticles, Scaffold

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