Fabrication of an ISFET Sensor for the Detection of Sodium Ions in Body Plasma

Article Preview

Abstract:

Sodium chloride, commonly known as table salt, is widely used as essential seasoning in food, snacks and deserts worldwide. However, excessive consumption of table salt is a major cause of various health issues, involving high blood pressure, liver cirrhosis, kidney disease, and heart failure. This research aims at creating a portable, low-powered, efficient sensor for detection of sodium ions in body plasma for medical diagnosis purpose. The device was fabricated on a platform of Ion-Sensitive Field-Effect Transistor (ISFET) modified with sodium ionophore (sodium recognizing element), entrapped in polyurethane thin film. Our preliminary studies show that sodium ionophore-modified ISFET sensor yields good sensing performances, having a maximum sensitivity of 43 mV/pNa, and a detection limit of 2.3 millimol/liter.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

190-196

Citation:

Online since:

October 2019

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2019 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] D. Laubitz, F.K. Ghishan, P.R. Kiela, Sodium: Basic Nutritional Aspects, in: J. Collins (Ed.), Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals, Academic Press, Boston, 2017, pp.489-501.

DOI: 10.1016/b978-0-12-802168-2.00040-3

Google Scholar

[2] M. Singh, S. Chandorkar, Is sodium and potassium content of commonly consumed processed packaged foods a cause of concern?, Food Chem. 238 (2018) 117-124.

DOI: 10.1016/j.foodchem.2016.11.108

Google Scholar

[3] G. Kaur, N. Kaur, Estimation of sodium ions using easily engineered organic nanoparticles-based turn-on fluorescent sensor: Application in biological and environmental samples. Sens Actuators B Chem. 265 (2018) 134-141.

DOI: 10.1016/j.snb.2018.02.063

Google Scholar

[4] G. Lindner, G.C. Funk, Hypernatremia in critically ill patients. J Crit Care. 28 (2013) 216.e11-216.e20.

DOI: 10.1016/j.jcrc.2012.05.001

Google Scholar

[5] S.A. Muhsin, D.B. Mount, Diagnosis and treatment of hypernatremia, Best Pract Res Clin Endocrinol Metab. 30 (2016) 189-203.

Google Scholar

[6] M. Terris, P. Crean, Fluid and electrolyte balance in children, Anaesth Intensive Care. 18 (2017) 567-571.

DOI: 10.1016/j.mpaic.2017.07.009

Google Scholar

[7] B. Paull, P.N. Nesterenko, Ion Chromatography, in: S. Fanali, P.R. Haddad, C.F. Poole, P. Schoenmakers, D. Lloyd (Eds), Liquid Chromatography, second ed., Elsevier, Amsterdam, 2013, pp.157-191.

DOI: 10.1016/b978-0-12-415807-8.00008-0

Google Scholar

[8] D. Beauchemin, Inductively Coupled Plasma Mass Spectrometry Methods, in: J.C. Lindon, G.E. Tranter, D.W. Koppenaal (Eds), Encyclopedia of Spectroscopy and Spectrometry, third ed., Academic Press, Oxford, 2017, pp.236-245.

DOI: 10.1016/b978-0-12-409547-2.11222-3

Google Scholar

[9] F.S. Diba, H.J. Lee, Amperometric sensing of sodium, calcium and potassium in biological fluids using a microhole supported liquid/gel interface, J. Electroanal. Chem. 769 (2016) 5-10.

DOI: 10.1016/j.jelechem.2016.02.045

Google Scholar

[10] D.W. Kwon, S. Kim, R. Lee, H.S. Mo, D.H. Kim, B.G. Park, Macro modeling of ion sensitive field effect transistor with current drift. Sens Actuators B Chem. 249 (2017) 564-570.

DOI: 10.1016/j.snb.2017.03.110

Google Scholar

[11] J. Artigas, C. Jiménez, C. Domı́nguez, S. Mı́nguez, A. Gonzalo, J. Alonso, Development of a multiparametric analyser based on ISFET sensors applied to process control in the wine industry. Sens Actuators B Chem. 89 (2003) 199-204.

DOI: 10.1016/s0925-4005(02)00464-1

Google Scholar

[12] R. Mlika, M. Gamoudi, G. Guillaud, M. Charbonnier, M. Romand, J. Davenas, N. Jaffrezic-Renault, R. Lamartine, A. Touhami, Calix[4]arene sensitive thin films for detecting sodium. Surface studies. Mater. Sci. Eng. C. 11 (2000) 129-136.

DOI: 10.1016/s0928-4931(00)00194-6

Google Scholar

[13] F. Sauvage, E. Baudrin, J.M. Tarascon, Study of the potentiometric response towards sodium ions of Na0.44−xMnO2 for the development of selective sodium ion sensors. Sens Actuators B Chem. 120 (2007) 638-644.

DOI: 10.1016/j.snb.2006.03.024

Google Scholar

[14] ACazalé, W. Sant, F. Ginot, J.C. Launay, G. Savourey, F. Revol-Cavalier, J.M. Lagarde, D. Heinry, J. Launay, P. Temple-Boyer, Physiological stress monitoring using sodium ion potentiometric microsensors for sweat analysis. Sens Actuators B Chem. 225 (2016) 1-9.

DOI: 10.1016/j.snb.2015.10.114

Google Scholar

[15] A. Cazalé, W. Sant, J. Launay, F. Ginot, P. Temple-Boyer, Study of field effect transistors for the sodium ion detection using fluoropolysiloxane-based sensitive layers, Sens Actuators B Chem. 177 (2013) 515-521.

DOI: 10.1016/j.snb.2012.11.054

Google Scholar

[16] X. Zhang, A. Fakler, U.E. Spichiger, Design of pH microelectrodes based on ETHT 2418 and their application for measurement of pH profile in instant noodles, Anal. Chim. Acta 445 (2001) 57-65.

DOI: 10.1016/s0003-2670(01)01252-1

Google Scholar