Bio-Properties of Zr-Based BMGMC as Potential Hard Tissue Implants

Abstract:

In this study, an in situ formed bulk metallic glass matrix composite (BMGMC) (Zr_58.5Ti_14.3Ni_4.9Cu_6.1Nb_5.2Be_11.0) was synthesized. Bulk metallic glass (BMG) (Zr5_2.5Cu_17.9Ni_14.6Al_10.0Ti_5.0) was also included in this work and a Ti-6Al-4V alloy was used as a reference material. Due to the glassy matrix that postpones the growth of corrosion pits, the BMGMC displays high positive corrosion potentials and low corrosion current densities. The BMGMC exhibited a higher improved corrosion resistance than the Ti alloys. Furthermore, the biocompatibility of this BMGMC was assessed by studying the cellular behavior of bone-forming mouse M3T3-E1 pre-osteoblast cells. The matrix did not significantly affect cell adhesion, proliferation and ALP activity. The general biosafety of Zr-based BMGMC for M3T3-E1 cells was revealed as normal cell responses. Zr-based BMGMC shows great potential for applications in the hard tissue implants.

• Periodical: Materials Science Forum (Volumes 745-746)
• Pages: 754-760
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.745-746.754
• Online since: February 2013
• Authors: Xiao Bo Huang, Nai Ming Lin, Rui Qiang Hang, Bin Tang, Jun Wei Qiao
• Keywords: Anticorrosion, Biocompatibility, Zr-Based BMGMC

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