Paper Titles

Preparation and Characterization of the Magnetic Layered Double Hydroxide - DNA Delivery System
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Hollow Nitrogen Rich Carbon Nanowire Array Electrode for Application in Lithium-Ion Battery
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HomeMaterials Science ForumMaterials Science Forum Vol. 914Preparation and Characterization of the Magnetic...

Preparation and Characterization of the Magnetic Layered Double Hydroxide - DNA Delivery System

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Abstract:

The purpose of this paper is to prepare and evaluate a gene delivery system resulted from the intercalation of DNA with magnetic layered double hydroxide (MLDH). The structure and property of the MLDH/DNA hybrids were studied using XRD, FTIR and TG characterization. The cytotoxicity and protection effect of MLDH were evaluated by MTT assay and gel electrophoresis assay. MLDH exhibited lower cytotoxicity than other inorganic nanoparticles. Under physiological conditions, MLDH could protect DNA from enzymatic degradation. Our results confirmed that MLDH can be used safely and effectively as non-viral vectors for gene targeting therapy in form of MLDH/DNA composite.

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Functional Materials Technology and Industry Forum IX

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Periodical:

Materials Science Forum (Volume 914)

Pages:

3-10

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.914.3

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Online since:

February 2018

Authors:

Guo Jing Gou*, Qin Yu Pei, Hui Qing Yao, Yue Sun, Jian Hong Yang, Rui Wang

Keywords:

Cytotoxicity, Gene Delivery System, Magnetic Layered Double Hydroxide, Nanoparticles, Protection against Degradation

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© 2018 Trans Tech Publications Ltd. All Rights Reserved

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