Bioactive Gelatin-Siloxane Hybrids as Tissue Engineering Scaffold

Lei Ren; Akiyoshi Osaka; B. Yu; Wei Shi; Dong Tao Ge; Song Chen; Qi Qing Zhang

doi:10.4028/www.scientific.net/SSP.111.13

Paper Titles

Biological Hybrid Materials for Drug Delivery System
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Mixed Phase Behavior in Hole-Doped Perovskite Materials
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Bioactive Gelatin-Siloxane Hybrids as Tissue Engineering Scaffold
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Hybrid MOS/CNTs Materials for Gas Sensing
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Sensitivity of Zn_1-xCd_x Te to Tera-Hertz Signals Enhanced by Structural Orderings
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Sol-Gel Synthesis and Structure-Property Relations in Zn_xCu_1-xBi₂O₄ (0≤ x ≤0.6) Spinels
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Microstructural Investigation of Particulate Reinforced Ti-Sn Metal Matrix Composites
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Synthesis and Characterization of Hybrid Aluminum Composites Reinforced with Ni Particulates and Interconnected Fe Mesh
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Naphthalene Containing Polyimide Nanocomposites Hybrid with Organo-Modified Montmorillonite
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Bioactive Gelatin-Siloxane Hybrids as Tissue Engineering Scaffold

Abstract:

Ca2+-containing porous gelatin-siloxane hybrids were prepared using sol-gel process, post-gelation soaking, and freeze-drying. The porosity and pore size of the hybrids could be well controlled by the freezing temperature and the pH value of the soaking solution. The pore characteristics were related to the structure change during the soaking treatment. A bone-like apatite layer was able to form in the Ca2+-containing porous gelatin-siloxane hybrids upon soaking in a stimulated body fluid. The porous gelatin-siloxane hybrids could release gentamicin sulfate which is an antibiotic drug in bone chemotherapy. Thus, those hybrid materials are proposed to find application as novel bioactive and biodegradable scaffolds in bone tissue engineering.